Generic Name: exenatide (ex-EN-a-tide)
Brand Name: Byetta
Byetta is used for:
Treating type 2 diabetes. It is used along with diet and exercise.
Byetta is a glucagon-like peptide-1 (GLP-1) receptor agonist. It lowers blood sugar by increasing the release of insulin from the pancreas. It also mimics the actions of certain hormones that lower blood sugar levels.
Do NOT use Byetta if:
- you are allergic to any ingredient in Byetta
- you have type 1 diabetes
- you have high blood or urine ketone levels caused by diabetes (diabetic ketoacidosis)
- you have severe kidney problems (including if you are on dialysis) or severe stomach or bowel problems
Contact your doctor or health care provider right away if any of these apply to you.
Before using Byetta:
Some medical conditions may interact with Byetta. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of stomach or bowel problems (eg, trouble digesting food or slowed emptying of the stomach), gallbladder problems (eg, gallstones), inflammation of the pancreas (pancreatitis), high blood triglyceride levels, alcohol abuse, kidney problems or kidney transplant, or pituitary or adrenal gland problems
- if you have severe diarrhea or vomiting, or you are dehydrated
- if you are also using insulin
- if you are taking lovastatin
Some MEDICINES MAY INTERACT with Byetta. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Insulin, meglitinides (eg, repaglinide), sulfonylureas (eg, glipizide), or thiazolidinediones (eg, pioglitazone) because the risk of low blood sugar may be increased
- Angiotensin-converting enzyme (ACE) inhibitors (eg, lisinopril), diuretics (eg, furosemide, hydrochlorothiazide), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), or other medicines that may affect kidney function (eg, aminoglycoside antibiotics [such as gentamicin, amphotericin B, cyclosporine, tacrolimus, vancomycin]) because the risk of kidney problems may be increased. Ask your doctor if you are unsure if any of your medicines might affect kidney function
- Anticoagulants (eg, warfarin) because the risk of their side effects may be increased by Byetta
Ask your health care provider if Byetta may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Byetta:
Use Byetta as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Byetta comes with an extra patient information sheet called a Medication Guide and a user manual for the pen. Read them carefully. Read them again each time you get Byetta refilled.
- Use Byetta within 1 hour before your morning and evening meals (or before the 2 main meals of the day), unless your doctor tells you otherwise. Do NOT use it after a meal. Your doses of Byetta should be about 6 hours or more apart.
- If you will be using Byetta at home, a health care provider will teach you how to use it. Be sure you understand how to use Byetta. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not mix Byetta with insulin. Do not transfer Byetta from the pen into a syringe or vial.
- Inject Byetta into your upper leg (thigh), stomach area (abdomen), or upper arm as directed by your doctor or other health care provider.
- Use the proper technique taught to you by your doctor. Inject deep under the skin, NOT into a vein or muscle.
- Do not use Byetta if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- If you are taking certain medicines by mouth (eg, antibiotics, birth control pills), you may need to take them at least 1 hour before you use Byetta. If you must take one of these medicines with food, take them with a meal or snack when you do not also take Byetta. Ask your doctor, pharmacist, or other health care provider if you need to take any of your medicines at a different time than Byetta.
- Do not share pen or cartridge devices with another person. Sharing these devices may pass infections from one person to another. This includes infections you may not know you have.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Byetta, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Byetta.
Important safety information:
- Byetta may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Byetta with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do NOT use more than the recommended dose without checking with your doctor.
- Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher than they should be and you take Byetta exactly as prescribed, tell your doctor.
- Follow the diet and exercise program given to you by your health care provider. Proper diet, regular exercise, and regular testing of blood sugar are important for best results when using Byetta.
- The risk of low blood sugar may be increased when Byetta is used with certain other diabetes medicines (eg, insulin, meglitinides, sulfonylureas, thiazolidinediones). Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you hungrier. It is a good idea to carry a reliable source of glucose (eg, tablets, gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or nondiet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
- It may be harder to control your blood sugar during times of stress, such as fever, infection, injury, or surgery. Talk with your doctor about how to control your blood sugar if any of these occur. Do not change the dose of your medicine without checking with your doctor.
- Byetta may decrease your appetite, the amount of food you eat, and your weight. This is normal. Do not change your dose of Byetta without checking with your doctor.
- Patients taking Byetta have developed a severe and sometimes fatal pancreas problem (pancreatitis). Contact your doctor right away if you develop severe or persistent stomach or back pain (with or without nausea or vomiting).
- If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
- Do not store the pen with the needle attached. If the needle is left on, the medicine may leak from the pen or air bubbles may form in the cartridge.
- Tell your doctor or dentist that you take Byetta before you receive any medical or dental care, emergency care, or surgery.
- Lab tests, including hemoglobin A1c levels, blood sugar levels, and kidney function, may be performed while you use Byetta. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Byetta with caution in the ELDERLY; they may be more sensitive to its effects.
- Byetta should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Byetta while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use Byetta, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Byetta:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Constipation; diarrhea; dizziness; feeling jittery; headache; indigestion; irritation or small bump at the injection site; nausea; vomiting; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); chest pain; fainting; fast or irregular heartbeat; pain, swelling, redness, or severe irritation at the injection site; severe dizziness; severe or persistent headache, diarrhea, nausea, or vomiting; severe or persistent stomach or back pain (with or without nausea or vomiting); symptoms of kidney problems (eg, change in the amount of urine produced, unusual or persistent pain in the mid to lower back, unexplained swelling); symptoms of low blood sugar (eg, chills, confusion, drowsiness, increased hunger, increased sweating, irritability, nervousness, tremor, blurred vision, weakness).
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include severe nausea or vomiting; symptoms of low blood sugar (eg, chills, confusion, drowsiness, fainting, fast heartbeat, increased hunger, increased sweating, irritability, nervousness, severe dizziness, tremor, blurred vision, weakness).Proper storage of Byetta:
Store unused (unopened) pens in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Do not use Byetta if it has been frozen. Store used (open) pens below 77 degrees F (25 degrees C). Protect from light. Do not store with the needle attached to the pen. Throw away a used pen 30 days after first use, even if some medicine remains in the pen. Do not use past the expiration date. Keep Byetta out of the reach of children and away from pets.
- If you have any questions about Byetta, please talk with your doctor, pharmacist, or other health care provider.
- Byetta is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Byetta or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Byetta. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Byetta. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Byetta.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about Byetta (exenatide)
- Other brands: Bydureon