Byetta Side Effects

Generic Name: exenatide

Note: This page contains information about the side effects of exenatide. Some of the dosage forms included on this document may not apply to the brand name Byetta.

Not all side effects for Byetta may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to exenatide: subcutaneous powder for suspension extended release, subcutaneous solution

In addition to its needed effects, some unwanted effects may be caused by exenatide (the active ingredient contained in Byetta). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking exenatide:

Incidence not known
  • Agitation
  • bloated or full feeling
  • chills
  • coma
  • confusion
  • constipation
  • cough
  • darkened urine
  • decreased urination or urine output
  • depression
  • difficulty with swallowing
  • dizziness
  • dry mouth
  • fainting
  • fast heartbeat
  • fever
  • headache
  • hives or welts
  • hostility
  • increase in heart rate
  • indigestion
  • irritability
  • itching skin
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lethargy
  • lightheadedness
  • loss of appetite
  • muscle twitching
  • nausea
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid breathing
  • rapid weight gain
  • seizures
  • shortness of breath
  • skin rash
  • stupor
  • sunken eyes
  • swelling of the face, ankles, or hands
  • thirst
  • tightness in the chest
  • unusual tiredness or weakness
  • vomiting
  • wheezing
  • wrinkled skin
  • yellow eyes or skin

If any of the following symptoms of overdose occur while taking exenatide, get emergency help immediately:

Symptoms of overdose
  • Anxiety
  • blurred vision
  • cold sweats
  • cool, pale skin
  • increased hunger
  • nervousness
  • nightmares
  • severe vomiting
  • shakiness
  • slurred speech

Some of the side effects that can occur with exenatide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Acid or sour stomach
  • belching
  • diarrhea
  • feeling jittery
  • heartburn
  • stomach discomfort or upset
Less common
  • Appetite decreased
  • increased sweating
  • lack or loss of strength
Incidence not known
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • change in taste
  • excess air or gas in the stomach or intestines
  • loss of taste
  • passing gas
  • pressure in the stomach
  • rash with flat lesions or small raised lesions on the skin
  • redness of the skin
  • sleepiness or unusual drowsiness
  • swelling of the abdomen or stomach area

For Healthcare Professionals

Applies to exenatide: subcutaneous powder for injection extended release, subcutaneous solution

Metabolic

Metabolic side effects have included hypoglycemia.

Most episodes of hypoglycemia were mild to moderate in intensity and all resolved with administration of carbohydrate. Hypoglycemia was rarely observed in patients treated with the combination of exenatide and metformin and was similar in incidence to patients treated with placebo and metformin. When used as add-on to a thiazolidinedione, with or without metformin, the incidence of symptomatic mild to moderate hypoglycemia with exenatide was 11% compared to 7% with placebo.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, diarrhea, and dyspepsia.

Nervous system

Nervous system side effects have included dizziness, headache and feeling jittery.

Immunologic

Immunologic side effects have included the development of anti exenatide (the active ingredient contained in Byetta) antibodies.

Dermatologic

Dermatologic side effects have included postmarketing reports of alopecia.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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