Generic name: bendamustine [ BEN-da-MUS-teen ]
Brand names: Belrapzo, Bendeka, Treanda, Vivimusta
Dosage forms: intravenous powder for injection (100 mg; 25 mg), intravenous solution (25 mg/mL)
Drug class: Alkylating agents

Medically reviewed by Drugs.com on Jun 27, 2022. Written by Cerner Multum.

What is bendamustine?

Bendamustine is used to treat chronic lymphocytic leukemia. Bendamustine is also used to treat indolent B-cell non-Hodgkin lymphoma after other medicines have been tried without successful treatment of this condition.

Bendamustine may also be used for purposes not listed in this medication guide.

Bendamustine side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Bendamustine may cause a brain infection that can lead to disability or death. Tell your doctor if you have problems with speech, thought, vision, or muscle movement. These symptoms can get worse quickly.

Bendamustine may cause serious side effects. Call your doctor at once if you have:

• fever, chills, or itching during or shortly after the injection;

• pain, swelling, redness, skin changes, or signs of infection where the medicine was injected;

• severe ongoing nausea, vomiting, or diarrhea;

• liver problems--right-sided upper stomach pain, vomiting, loss of appetite, yellowing of your skin or eyes, and not feeling well;

• low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or

• signs of tumor cell breakdown--confusion, weakness, muscle cramps, nausea, vomiting, fast or slow heart rate, decreased urination, tingling in your hands and feet or around your mouth.

Your cancer treatments may be delayed if you have certain side effects.

Common side effects of bendamustine may include:

• fever, cough, mouth sores, trouble breathing;

• low blood cell counts;

• nausea, vomiting, diarrhea, constipation;

• headache, tiredness;

• rash; or

• loss of appetite, weight loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Imbruvica, Carvykti, Jaypirca, Velcade, Tecvayli, Venclexta, methotrexate

Warnings

Tell your caregivers right away if you have any type of skin rash after being treated with bendamustine.

Before taking this medicine

You should not be treated with bendamustine if you are allergic to bendamustine, polyethylene glycol, propylene glycol, or mannitol (Osmitrol).

Tell your doctor if you have ever had:

• a weak immune system;

• fever or other signs of infection;

• tuberculosis;

• herpes zoster (also called shingles)

• a metabolic disorder or electrolyte imbalance;

• liver disease;

• kidney disease; or

• if you smoke.

Using bendamustine may increase your risk of developing certain types of cancer. Ask your doctor about this risk.

Bendamustine can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.

• If you are a woman, do not use bendamustine if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.

• If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.

• Tell your doctor right away if a pregnancy occurs while either the mother or the father is using bendamustine.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because bendamustine can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

How is bendamustine given?

Bendamustine is given as an infusion into a vein. A healthcare provider will give you this injection.

Bendamustine is usually given for 2 days in a row every 21 to 28 days. Your doctor will determine how long to treat you with this medicine.

You may be given other medications to help prevent certain side effects of bendamustine.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when the medicine is injected.

Bendamustine affects your immune system. You may get infections more easily, even serious or fatal infections. Your doctor will need to examine you on a regular basis.

If you've ever had hepatitis B, using bendamustine can cause this virus to become active or get worse. You may need frequent liver function tests while using this medicine and for several months after you stop.

Bendamustine dosing information

Usual Adult Dose for Chronic Lymphocytic Leukemia:

100 mg/m2 IV on Days 1 and 2 of a 28-day cycle
Duration of Therapy: Up to 6 cycles

Comments:
-Administer this drug via IV infusion over 30 minutes; consult the manufacturer product information for specific IV infusion time period.
-Efficacy of this drug relative to first-line therapies other than chlorambucil has not been established.
-This drug is available in two formulations, a solution and a lyophilized powder; do not mix or combine the two formulations.

Use: For the treatment of patients with chronic lymphocytic leukemia

Usual Adult Dose for non-Hodgkin's Lymphoma:

120 mg/m2 IV on Days 1 and 2 of a 21-day cycle
Duration of Therapy: Up to 8 cycles

Comments:
-Administer this drug via IV infusion over 60 minutes; consult the manufacturer product information for specific IV infusion time period.
-This drug is available in two formulations, a solution and a lyophilized powder; do not mix or combine the two formulations.

Use: For the treatment of patients with indolent B-cell non-Hodgkin lymphoma that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your bendamustine injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving bendamustine?

Avoid driving or hazardous activity until you know how bendamustine will affect you. Your reactions could be impaired.

What other drugs will affect bendamustine?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your other medicines, especially:

• allopurinol.

This list is not complete. Other drugs may affect bendamustine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Frequently asked questions

• Are lung nodules common after Bendeka & Rituxan therapy?
• How is Bendeka different to Treanda?
• Why has Bendeka replaced Treanda?
• How often is Bendeka given and how long does treatment last?
• Does Treanda cause hair loss?
• What is Treanda used for and how does it work?
• What is Bendeka used for?

View more FAQ

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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