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Bendamustine Pregnancy and Breastfeeding Warnings

Bendamustine is also known as: Treanda

Bendamustine Pregnancy Warnings

If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.

Bendamustine has been assigned to pregnancy category D by the FDA. Animal studies have revealed skeletal and visceral malformations (exencephaly, cleft palates, accessory rib, and spinal deformities), decreased fetal body weights, a significant increase in external and internal malformations, as well as embryo and fetal lethality as indicated by increased resorptions and a decrease in live fetuses. There are no controlled data in human pregnancy. Bendamustine should only be given during pregnancy when there are no alternatives and benefit outweighs risk.

Bendamustine Breastfeeding Warnings

There are no data on the excretion of bendamustine into human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants and tumorigenicity shown for bendamustine in animal studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

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