Allergies? Get expert advice on treating severe allergies and anaphylaxis.

Acetaminophen/ chlorpheniramine/ phenylephrine effervescent tablets

Generic Name: acetaminophen/chlorpheniramine/phenylephrine (a-SEET-a-MIN-oh-fen/KLOR-fen-IR-a-meen/FEN-il-EF-rin)
Brand Name: GNP Cold Relief Plus

Acetaminophen/ chlorpheniramine/ phenylephrine effervescent tablets is used for:

Relieving symptoms of colds, such as headache, minor aches and pain, nasal and sinus congestion, sneezing, runny nose, fever, and sore throat. It may also be used for other conditions as determined by your doctor.

Acetaminophen/chlorpheniramine/phenylephrine effervescent tablets is an antihistamine, decongestant, and pain reliever/fever reducer combination. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as sneezing and runny nose. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages. The pain reliever/fever reducer works in the brain to decrease pain and reduce fever.

Do NOT use acetaminophen/ chlorpheniramine/ phenylephrine effervescent tablets if:

  • you are allergic to any ingredient in acetaminophen/chlorpheniramine/phenylephrine effervescent tablets
  • you have severe or uncontrolled high blood pressure, severe heart blood vessel disease, a rapid heartbeat, or severe heart problems
  • you are unable to urinate or are having an asthma attack
  • you are taking another medicine (prescription or nonprescription) that contains acetaminophen
  • you are taking droxidopa or sodium oxybate (GHB) or have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Video: Asthma

How to prevent and treat an asthma attack.

Before using acetaminophen/ chlorpheniramine/ phenylephrine effervescent tablets:

Some medical conditions may interact with acetaminophen/chlorpheniramine/phenylephrine effervescent tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of adrenal gland problems (eg, adrenal gland tumor), heart problems (eg, cor pulmonale; fast, slow, or irregular heartbeat; heart disease), high blood pressure, diabetes, blood vessel problems, stroke, glaucoma or increased pressure in the eye, seizures, phenylketonuria (PKU), liver problems (eg, hepatitis), kidney problems, stomach or bowel ulcers, or thyroid problems
  • if you have a history of asthma, chronic obstructive pulmonary disease (COPD), other lung or breathing problems (eg, chronic bronchitis, emphysema, sleep apnea), or chronic cough
  • if you have a blockage of your bladder, stomach, or bowels; trouble sleeping; an enlarged prostate or other prostate problems; or trouble urinating
  • if you drink alcohol or have a history of alcohol abuse
  • if you are on a low-salt diet
  • if you are taking medicine to treat high blood pressure

Some MEDICINES MAY INTERACT with acetaminophen/chlorpheniramine/phenylephrine effervescent tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin) because the risk of bleeding may be increased
  • Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), furazolidone, linezolid, MAOIs (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of acetaminophen/chlorpheniramine/phenylephrine effervescent tablets's side effects
  • Bromocriptine or hydantoins (eg, phenytoin) because the risk of their side effects may be increased by acetaminophen/chlorpheniramine/phenylephrine effervescent tablets
  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by acetaminophen/chlorpheniramine/phenylephrine effervescent tablets
  • Medicines that may harm the liver (eg, methotrexate, ketoconazole, isoniazid, certain medicines for HIV infection) because the risk of liver side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the liver

This may not be a complete list of all interactions that may occur. Ask your health care provider if acetaminophen/chlorpheniramine/phenylephrine effervescent tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use acetaminophen/ chlorpheniramine/ phenylephrine effervescent tablets:

Use acetaminophen/chlorpheniramine/phenylephrine effervescent tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take acetaminophen/chlorpheniramine/phenylephrine effervescent tablets by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Do not chew or swallow the tablet. Place the tablet(s) in a glass and add about 4 oz/120 mL of cold water. Allow the tablet to dissolve completely; then drink all of the liquid. Rinse the container with an additional small amount of water and drink the contents to ensure the entire dose is taken.
  • Do not take more than 8 tablets in 24 hours.
  • If you miss a dose of acetaminophen/chlorpheniramine/phenylephrine effervescent tablets and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use acetaminophen/chlorpheniramine/phenylephrine effervescent tablets.

Important safety information:

  • Acetaminophen/chlorpheniramine/phenylephrine effervescent tablets may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use acetaminophen/chlorpheniramine/phenylephrine effervescent tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol while you are using acetaminophen/chlorpheniramine/phenylephrine effervescent tablets.
  • Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using acetaminophen/chlorpheniramine/phenylephrine effervescent tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Acetaminophen/chlorpheniramine/phenylephrine effervescent tablets has acetaminophen, chlorpheniramine, and phenylephrine in it. Before you start any new medicine, check the label to see if it has any of these medicines in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Do not take diet or appetite control medicines while you are taking acetaminophen/chlorpheniramine/phenylephrine effervescent tablets without checking with your doctor.
  • Acetaminophen/chlorpheniramine/phenylephrine effervescent tablets may harm your liver. Your risk may be greater if you drink alcohol while you are taking acetaminophen/chlorpheniramine/phenylephrine effervescent tablets. Talk to your doctor before you take acetaminophen/chlorpheniramine/phenylephrine effervescent tablets or other fever reducers if you drink alcohol.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
  • Contact your doctor right away if you take more than 4,000 mg of acetaminophen per day, even if you feel well.
  • If you have a sore throat that is severe, persists for more than 2 days, or occurs with fever, headache, rash, nausea, or vomiting, check with your doctor.
  • Contact your doctor if you have a fever that gets worse or lasts for more than 3 days.
  • If new symptoms occur, if redness or swelling is present, or if pain or nasal congestion gets worse or lasts more than 7 days, check with your doctor.
  • Acetaminophen/chlorpheniramine/phenylephrine effervescent tablets contains phenylalanine. If you must have a diet that is low in phenylalanine, check with your doctor or pharmacist.
  • If you have trouble sleeping, ask your doctor or pharmacist about the best time of the day to take acetaminophen/chlorpheniramine/phenylephrine effervescent tablets.
  • Acetaminophen/chlorpheniramine/phenylephrine effervescent tablets may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to acetaminophen/chlorpheniramine/phenylephrine effervescent tablets. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Acetaminophen/chlorpheniramine/phenylephrine effervescent tablets may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking acetaminophen/chlorpheniramine/phenylephrine effervescent tablets for a few days before the tests.
  • Tell your doctor or dentist that you take acetaminophen/chlorpheniramine/phenylephrine effervescent tablets before you receive any medical or dental care, emergency care, or surgery.
  • Use acetaminophen/chlorpheniramine/phenylephrine effervescent tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion, dizziness, drowsiness, dry mouth, nervousness, sleeplessness, and trouble urinating.
  • Caution is advised when using acetaminophen/chlorpheniramine/phenylephrine effervescent tablets in CHILDREN; they may be more sensitive to its effects, especially excitability.
  • Acetaminophen/chlorpheniramine/phenylephrine effervescent tablets should not be used in CHILDREN younger than 12 years old without first checking with the child's doctor; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking acetaminophen/chlorpheniramine/phenylephrine effervescent tablets while you are pregnant. It is not known if acetaminophen/chlorpheniramine/phenylephrine effervescent tablets is found in breast milk. Do not breast-feed while taking acetaminophen/chlorpheniramine/phenylephrine effervescent tablets.

Possible side effects of acetaminophen/ chlorpheniramine/ phenylephrine effervescent tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; loss of appetite; nausea; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; confusion; difficulty urinating or inability to urinate; fast or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; mental or mood changes (eg, nervousness); restlessness; seizures; severe or persistent dizziness, drowsiness, light-headedness, or headache; severe or persistent trouble sleeping; symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, stomach pain, yellowing of the skin or eyes); tremors; unusual bruising or bleeding; unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; nausea; ringing in the ears; seizures; severe dizziness, drowsiness, light-headedness, or headache; symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, stomach pain, yellowing of the skin or eyes); tremors; unusually fast, slow, or irregular breathing; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of acetaminophen/chlorpheniramine/phenylephrine effervescent tablets:

Store acetaminophen/chlorpheniramine/phenylephrine effervescent tablets at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep acetaminophen/chlorpheniramine/phenylephrine effervescent tablets out of the reach of children and away from pets.

General information:

  • If you have any questions about acetaminophen/chlorpheniramine/phenylephrine effervescent tablets, please talk with your doctor, pharmacist, or other health care provider.
  • Acetaminophen/chlorpheniramine/phenylephrine effervescent tablets is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take acetaminophen/chlorpheniramine/phenylephrine effervescent tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about acetaminophen/chlorpheniramine/phenylephrine effervescent tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to acetaminophen/chlorpheniramine/phenylephrine effervescent tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using acetaminophen/chlorpheniramine/phenylephrine effervescent tablets.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

Severe allergies and anaphylaxis: Learn how epinephrine can save a life. Watch Video

Close
Hide
(web5)