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Abciximab

Generic Name: abciximab (ab-SIX-i-mab)
Brand Name: ReoPro

Abciximab is used for:

Preventing serious heart problems in patients undergoing a procedure called percutaneous coronary intervention (PCI). It is also used in certain patients with unstable angina (chest pain) to prevent serious heart problems when PCI is planned. Abciximab is used in combination with other medicines.

Abciximab is a platelet aggregation inhibitor. It works by blocking platelets from sticking together to form blood clots.

Do NOT use abciximab if:

  • you are allergic to any ingredient in abciximab or to murine proteins
  • you have active internal bleeding, low blood platelet count, or other bleeding or clotting problems
  • you have had stomach, bowel, or urinary bleeding or major surgery or trauma within the past 6 weeks
  • you have had a stroke within the past 2 years
  • you have severe uncontrolled high blood pressure or a history of blood vessel inflammation (vasculitis)
  • you have had a growth or cancer of the brain, an aneurysm, or problems with blood vessels in the brain
  • you are or will be receiving dextran by injection
  • you are receiving or have received an anticoagulant (eg, warfarin) within the last 7 days

Contact your doctor or health care provider right away if any of these apply to you.

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Before using abciximab:

Some medical conditions may interact with abciximab. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of bleeding or clotting problems

Some MEDICINES MAY INTERACT with abciximab. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin, heparin), dipyridamole, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), ticlopidine, or thrombolytics (tissue plasminogen activators) because the risk of bleeding may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if abciximab may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use abciximab:

Use abciximab as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Abciximab is usually administered as an injection at your doctor's office, hospital, or clinic. Ask your doctor any questions that you may have about abciximab.
  • If you miss a dose of abciximab, contact your doctor right away.

Ask your health care provider any questions you may have about how to use abciximab.

Important safety information:

  • Abciximab may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use abciximab with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Severe and sometimes fatal bleeding has occurred in patients taking abciximab. The risk may be greater when used with medicines that thin the blood. Avoid activities that may cause bruising or injury. Contact your doctor right away if you experience unusual bruising or bleeding (eg, bleeding gums; nosebleeds; bleeding in the eye; blood in the urine; black, bloody, or tarry stools; coughing up blood; vomiting blood or material that looks like coffee grounds; severe or unusual vaginal bleeding); severe stomach pain; confusion; or severe or persistent headache or dizziness.
  • LAB TESTS, including complete blood cell counts and blood clotting tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Abciximab is not recommended for use in CHILDREN; safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using abciximab during pregnancy. It is not known if abciximab is found in breast milk. Do not breast-feed while taking abciximab.

Possible side effects of abciximab:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; dizziness; headache; nausea; pain at injection site; stomach pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; chills; fainting; fever; increased menstrual bleeding; pain, redness, or swelling at the injection site; severe or persistent dizziness, headache, or light-headedness; slow heartbeat; swelling of the hands, ankles, or feet.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of abciximab:

Abciximab is handled and stored by a health care provider. Keep abciximab out of the reach of children and away from pets.

General information:

  • If you have any questions about abciximab, please talk with your doctor, pharmacist, or other health care provider.
  • Abciximab is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take abciximab or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about abciximab. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to abciximab. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using abciximab.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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