Tolbutamide use while Breastfeeding
Drugs containing Tolbutamide: Orinase, Tol-Tab
Tolbutamide Levels and Effects while Breastfeeding
Summary of Use during Lactation
Tolbutamide is excreted into breastmilk in small amounts that should cause no harm to the breastfed infant. Monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with hypoglycemic agents.[1][2]
Drug Levels
Maternal Levels. In 2 women who were 3 days postpartum, milk levels were measured 4 hours after ingestion of a 500 mg dose of tolbutamide. Milk levels averaged 18 mg/L in one and 3 mg/L in the other.[3]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Possible Effects on Lactation
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
Acarbose, Chlorpropamide, Glyburide, Insulin, Metformin
References
1. Everett JA. Use of oral antidiabetic agents during breastfeeding. J Hum Lact. 1997;13:319-21. PMID: 9429368
2. Berlin CM, Briggs GG. Drugs and chemicals in human milk. Semin Fetal Neonatal Med. 2005;10:149-59. PMID: 15701580
3. Moiel RH, Ryan JR. Tolbutamide Orinase in human breast milk. Clin Pediatr. 1967;8:480. PMID: 6029660
Tolbutamide Identification
Substance Name
CAS Registry Number
64-77-7
Drug Class
- Hypoglycemic Agents
- Sulfonylurea Compounds
Administrative Information
LactMed Record Number
262
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
2011-01-04
Disclaimer
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
See Also...
- Tolbutamide use during Pregnancy
- Tolbutamide Consumer Information
- Breastfeeding Support Group
- Safe Medications during Breastfeeding
- Medicine use while Breastfeeding
- Medicine use during Pregnancy
Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.
