Tolbutamide use while Breastfeeding

Drugs containing Tolbutamide: Orinase, Tol-Tab

Tolbutamide Levels and Effects while Breastfeeding

Summary of Use during Lactation

Tolbutamide is excreted into breastmilk in small amounts that should cause no harm to the breastfed infant. Monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with hypoglycemic agents.[1][2]

Drug Levels

Maternal Levels. In 2 women who were 3 days postpartum, milk levels were measured 4 hours after ingestion of a 500 mg dose of tolbutamide. Milk levels averaged 18 mg/L in one and 3 mg/L in the other.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Acarbose, Chlorpropamide, Glyburide, Insulin, Metformin

References

1. Everett JA. Use of oral antidiabetic agents during breastfeeding. J Hum Lact. 1997;13:319-21. PMID: 9429368

2. Berlin CM, Briggs GG. Drugs and chemicals in human milk. Semin Fetal Neonatal Med. 2005;10:149-59. PMID: 15701580

3. Moiel RH, Ryan JR. Tolbutamide Orinase in human breast milk. Clin Pediatr. 1967;8:480. PMID: 6029660

Tolbutamide Identification

Substance Name

Tolbutamide

CAS Registry Number

64-77-7

Drug Class

  • Hypoglycemic Agents
  • Sulfonylurea Compounds

Administrative Information

LactMed Record Number

262

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

See Also...

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

Hide
(web3)