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Dicloxacillin use while Breastfeeding

Drugs containing Dicloxacillin: Dynapen, Pathocil, Dycill

Dicloxacillin Levels and Effects while Breastfeeding

Summary of Use during Lactation

Dicloxacillin is acceptable to use during breastfeeding and is frequently used to treat mastitis in nursing mothers.[1][2] Limited information indicates that dicloxacillin levels in milk are low and are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated.

Drug Levels

Maternal Levels. After a single oral dose of 250 mg of dicloxacillin in 2 women, milk levels ranged from 0.2 to 0.3 mg/L between 2 and 4 hours after the dose. The drug was undetectable in milk at 1 and 6 hours after the dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

References

1. Anon. ABM clinical protocol #4: mastitis. Revision, May 2008. Breastfeed Med. 2008;3:177-80. PMID: 18778213

2. Berth WL, Schauberger CW, Alvarado MA, Mathiason MA. Telephone-based management of lactation mastitis. J Reprod Med. 2009;54:291-4. PMID: 19517693

3. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy. 1984;5:57-60. PMID: 6743732

Dicloxacillin Identification

Substance Name

Dicloxacillin

CAS Registry Number

3116-76-5

Drug Class

Administrative Information

LactMed Record Number

90

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

See Also...

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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