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Vancomycin use while Breastfeeding

Drugs containing Vancomycin: Vancocin, Vancocin HCl Pulvules, Vancocin HCl, Lyphocin

Vancomycin Levels and Effects while Breastfeeding

Summary of Use during Lactation

Limited information indicates that vancomycin produces low levels in milk and it would not be expected to be absorbed or cause any adverse effects in breastfed infants. No special precautions are required.

Drug Levels

Maternal Levels. A single milk level of 12.7 mg/L was found 4 hours after the end of the infusion of vancomycin 1 gram intravenously given every 12 hours in one woman. Her peak and trough serum levels were 36.1 and 12.5 mg/L, respectively. The milk was obtained during the third trimester of pregnancy at a gestational age of about 35 to 38 weeks.[1] Using the serum level reported, an exclusively breastfed infant would receive 1.9 mg/kg daily by mouth in breastmilk. This dose is only about 4.8% of the oral vancomycin dose of 40 mg/kg daily used to treat pseudomembranous colitis in infants.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Daptomycin

References

1. Reyes MP, Ostrea Jr. EM, Cabinian AE et al. Vancomycin during pregnancy: does it cause hearing loss or nephrotoxicity in the infant? Am J Obstet Gynecol. 1989;161:977-81. PMID: 2801848

Vancomycin Identification

Substance Name

Vancomycin

CAS Registry Number

1404-90-6

Drug Class

  • Antiinfective Agents
  • Antibacterial Agents
  • Glycopeptides

Administrative Information

LactMed Record Number

394

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

See Also...

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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