Dicloxacillin Side Effects

Some side effects of dicloxacillin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to dicloxacillin: oral capsule

Get emergency medical help if you have any of these signs of an allergic reaction while taking dicloxacillin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

• diarrhea that is watery or bloody;

• fever, chills, body aches, flu symptoms;

• easy bruising or bleeding, unusual weakness;

• urinating less than usual or not at all;

• severe skin rash, itching, or peeling;

• agitation, confusion, unusual thoughts or behavior; or

• seizure (black-out or convulsions).

Less serious side effects of dicloxacillin may include:

• nausea, vomiting, stomach pain;

• vaginal itching or discharge;

• headache;

• swollen, black, or "hairy" tongue; or

• thrush (white patches or inside your mouth or throat).

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

For Healthcare Professionals

Applies to dicloxacillin: oral capsule, oral powder for reconstitution

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, diarrhea, stomatitis, black or hairy tongue, epigastric discomfort, flatulence, loose stools, and pseudomembranous colitis.

Hematologic

Hematologic side effects have included neutropenia, leukopenia, and thrombocytopenia. Other penicillins have been associated with agranulocytosis and bone marrow depression.

Hepatic

Hepatic side effects have included transient changes in SGOT, hepatotoxicity, and cholestatic hepatitis. Serum transaminase levels may take several weeks to return to normal following discontinuation of therapy.

Hypersensitivity

Hypersensitivity reactions have included rash, fever, eosinophilia, pruritus, urticaria, angioneurotic edema, anaphylactic reactions (bronchospasm, hypotension, vascular collapse, death), laryngeal edema, laryngospasm, serum-sickness-like symptoms, fever, chills and myalgias.

Renal

Renal side effects have rarely included renal failure. Increases in serum creatinine and acute renal failure have been reported with higher doses (3 to 4 grams daily) using an intravenous formulation, in postoperative patients with advanced age. Other penicillins have been associated with renal tubular damage and interstitial nephritis (rash, fever, eosinophilia, hematuria, proteinuria, renal insufficiency).

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