Dicloxacillin Side Effects
For the Consumer
Applies to dicloxacillin: oral capsules
Side effects include:
GI effects (nausea, vomiting, epigastric distress, loose stools, diarrhea, flatulence); hypersensitivity reactions.
For Healthcare Professionals
Applies to dicloxacillin: oral capsule, oral powder for reconstitution
Gastrointestinal side effects have included nausea, vomiting, diarrhea, stomatitis, black or hairy tongue, epigastric discomfort, flatulence, loose stools, and pseudomembranous colitis.[Ref]
Hematologic side effects have included neutropenia, leukopenia, and thrombocytopenia. Other penicillins have been associated with agranulocytosis and bone marrow depression.[Ref]
Hepatic side effects have included transient changes in SGOT, hepatotoxicity, and cholestatic hepatitis. Serum transaminase levels may take several weeks to return to normal following discontinuation of therapy.[Ref]
Hypersensitivity reactions have included rash, fever, eosinophilia, pruritus, urticaria, angioneurotic edema, anaphylactic reactions (bronchospasm, hypotension, vascular collapse, death), laryngeal edema, laryngospasm, serum-sickness-like symptoms, fever, chills and myalgias.[Ref]
Renal side effects have rarely included renal failure. Increases in serum creatinine and acute renal failure have been reported with higher doses (3 to 4 grams daily) using an intravenous formulation, in postoperative patients with advanced age. Other penicillins have been associated with renal tubular damage and interstitial nephritis (rash, fever, eosinophilia, hematuria, proteinuria, renal insufficiency).[Ref]
1. "Product Information. Dynapen (dicloxacillin)." Apothecon Inc, Plainsboro, NJ.
2. Kleinman MS, Presberg JE "Cholestatic hepatitis after dicloxacillin-sodium therapy." J Clin Gastroenterol 8 (1986): 77-8
3. Olsson R, Wiholm BE, Sand C, Zettergren L, Hultcrantz R, Myrhed M "Liver damage drom flucloxacillin, cloxacillin and dicloxacillin." J Hepatol 15 (1992): 154-61
4. Siegmund JB, Tarshis AM "Prolonged jaundice after dicloxacillin therapy." Am J Gastroenterol 88 (1993): 1299-300
5. Saab S, Venkataramani A, Yao F "Possible granulomatous hepatitis after dicloxacillin therapy." J Clin Gastroenterol 22 (1996): 163-4
6. Shelley WB, Shelley ED "Shoreline nails: sign of drug-induced erythroderma." Cutis Mar (1985): 220-2
7. Wahlstrom O, Maller R, Larsson R, Kagedal B "Effects of hip arthroplasty and peroperative dicloxacillin prophylaxis on renal function." Scand J Infect Dis 24 (1992): 85-8
8. Isacson J, Collert S "Renal impairment after high doses of dicloxacillin-prophylaxis in joint replacement surgery." Acta Orthop Scand 55 (1984): 407-10
9. Nordbring F "Is dicloxacillin nephrotoxic." Acta Orthop Scand 55 (1984): 405-6
Not all side effects for dicloxacillin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
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