What time of day should a Deplin tablet be taken?

I don't think it matters what time of the day it is taken. Perhaps try to take it at the same time each day. You may take Deplin (l-methylfolate) with or without food.

Use this product exactly as prescribed by your doctor and do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.
Use only the brand and strength of l-methylfolate that your doctor has prescribed. Do not switch brands without your doctor's advice.

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