I've been taking Deplin for almost a month along with other vitamins. I noticed a difference after about a week or so and have felt much more relaxed, energized and have let things that would normally bother me just roll off my shoulders. The only downfall are the headaches I've had almost daily. I had bad headaches daily for the first few wks, although they now seem more tolerable they still continue. Does anyone have any experience with this and/or suggestions on managing them?