I have tried amatiza a year ago and was too violent then eventually didn't go. And I can't go a day without having a BM or I will be miserable in pain. Took the 145 for the first time today and didn't go enough so tonight am hurting. Can I take 2 of the 145's to make the 290 strength? I have been on dulcolax, and many other laxatives and have gottn to where I have to take double what I used to to get the relief I need.