ZOFRAN SUPPOSITORIES 16MG

Active substance: ONDANSETRON

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5 How to store Zofran suppositories
• Keep out of the reach and sight of children.
• Do not use Zofran suppositories after the expiry date
which is stated on the pack after ‘Exp’.
• Do not store Zofran suppositories above 30°C.
• Zofran suppositories should only be taken out of the
blister immediately before use.
• If your doctor tells you to stop using Zofran suppositories,
it is important to return any which are left over to your
pharmacist.
6 Further information
What Zofran suppositories contain
• The active ingredient is ondansetron. Each Zofran
suppository contains ondansetron 16 mg.
• The other ingredient is Witespol S58
What Zofran suppositories look like and contents of the pack
Zofran suppository is white and torpedo shaped. Each
suppository is in an individually sealed cavity enclosed in a
perforated cardboard mount and packed into a carton.
Marketing Authorisation Holder and Manufacturer
Marketing Authorisation holder:
Glaxo Wellcome UK Ltd, trading as GlaxoSmithKline UK,
Stockley Park West, Uxbridge, Middlesex UB11 1BT
Manufacturer:
Farmaclair, Herouville Saint-Clair, France
Other formats:
To listen to or request a copy of this leaflet in Braille, large
print or audio please call, free of charge:

0800 198 5000 (UK only).
Please be ready to give the following information:
Product name
Zofran suppositories
Reference number
10949/0247
This is a service provided by the Royal National Institute of
Blind People.
Leaflet date: January 2012
Zofran is a registered trademark of the GlaxoSmithKline
group of companies
© 2012 GlaxoSmithKline group of companies

Package Leaflet: Information for the User

Zofran® suppositories 16 mg
ondansetron
Read all of this leaflet carefully before you start using this
medicine.
• Keep this leaflet. You may need to read it again.
• If you have any further questions about your illness or
your medicine, ask your doctor, nurse or pharmacist.
• This medicine has been prescribed for you. Do not pass it
on to others. It may harm them, even if their symptoms
are the same as yours.
• If any of the side effects get serious, or if you notice
any side effects not listed in this leaflet, please tell your
doctor, nurse or pharmacist.
In this leaflet:
1 What Zofran suppositories are and what they are used for
2 Before you use Zofran suppositories
3 How to use Zofran suppositories
4 Possible side effects
5 How to store Zofran suppositories
6 Further information
1 What Zofran suppositories are and what they are used for
Zofran suppositories contain a medicine called ondansetron.
This belongs to a group of medicines called anti-emetics.
Zofran suppositories are for use in your back passage only
(rectal use). They should not be swallowed.
Zofran suppositories are used for:
• preventing nausea and vomiting caused by chemotherapy
or radiotherapy for cancer
Ask your doctor, nurse or pharmacist if you would like any
further explanation about these uses.
2 Before you use Zofran suppositories
Do not use Zofran suppositories if:
• you are taking apomorphine (used to treat Parkinson’s
disease)
• you are allergic (hypersensitive) to ondansetron or
Witespol S58 in Zofran suppositories.
If you are not sure, talk to your doctor, nurse or pharmacist
before using Zofran suppositories.
Take special care with Zofran suppositories
Check with your doctor or pharmacist before using Zofran
suppositories if:
• you have ever had heart problems
• you have an uneven heart beat (arrhythmias)
• you are allergic to medicines similar to ondansetron, such
as granisetron (known as ‘Kytril’)
• you have liver problems
• you have a blockage in your gut
• you have problems with the levels of salts in your blood,
such as potassium, sodium and magnesium.
If you are not sure if any of the above apply to you, talk to
your doctor, nurse or pharmacist before using Zofran
suppositories.
Taking other medicines
Please tell your doctor, nurse or pharmacist if you are taking
or have recently taken any other medicines.
This includes medicines that you buy without
TURN OVER
a prescription and herbal medicines.

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This is because Zofran can affect the way some medicines
work. Also some other medicines can affect the way Zofran
works.
In particular, tell your doctor, nurse or pharmacist if you are
taking any of the following medicines:
• carbamazepine or phenytoin used to treat epilepsy
• rifampicin used to treat infections such as tuberculosis (TB)
• anti-arrhythmic medicines used to treat an uneven heart
beat
• beta-blocker medicines used to treat certain heart or eye
problems, anxiety or prevent migraines
• tramadol, a pain killer
• medicines that affect the heart (such as haloperidol or
methadone)
• cancer medicines (especially anthracyclines and
trastuzumab).
If you are not sure if any of the above applies to you, talk
to your doctor, nurse or pharmacist before using Zofran
suppositories.
Pregnancy and breast-feeding
It is not known if Zofran is safe during pregnancy. Talk to
your doctor before using Zofran suppositories if you are
pregnant or might become pregnant.
Do not breast-feed if you are using Zofran. This is because
small amounts pass into the mother’s milk. Ask your doctor
or midwife for advice.
3 How to use Zofran suppositories
Always use Zofran suppositories exactly as your doctor
has told you. You should check with your doctor, nurse or
pharmacist if you are not sure.
Dosage
On the day of chemotherapy or radiotherapy:
• the usual dose is one suppository (16 mg) to be inserted
1 to 2 hours before treatment.
On the following days:
• the usual dose is one suppository (16 mg) each day
• this may be repeated for up to 5 days.
Children
Zofran suppositories are not recommended for children.
Patients with moderate or severe liver problems
You should use Zofran as injection or tablets because the
total daily dose should not be more than 8 mg.

Using Zofran suppositories
1. Empty your bowels if you need to. Wash your hands.
2. Remove the suppository from its packaging by tearing
the foil (see illustration on pack)
3. You may find that inserting the suppository is easier if
you squat or bend forward
4. Gently push the pointed end of the suppository into the
back passage (rectum)
5. Push the suppository in as far as possible and remain still
for a little while. This allows the suppository to melt so
the medicine will work
6. Wash your hands
7. Try not to empty your bowels within 1 hour of inserting
the suppository.
8. If your suppository comes out of your back passage, push
it back in as far as possible and remain still for a while.
Wash your hands again.

2

If you keep feeling or being sick
Zofran suppositories should start to work within one or two
hours of using a dose.
If you continue to feel sick or are sick then tell your doctor
or nurse. Do not use the suppositories more often than the
label says.
If you use more Zofran suppositories than you should
If you use more Zofran suppositories than you should, or
accidentally swallow one, talk to a doctor or go to a
hospital straight away. Take the medicine pack with you.
If
If



you forget to use Zofran suppositories
you miss a dose and feel sick or vomit:
use a Zofran suppository as soon as possible, then
use your next suppository at the usual time (as shown on
the label)
• do not use a double dose to make up for a forgotten
dose.
If you miss a dose but do not feel sick
• use the next dose as shown on the label
• do not use a double dose to make up for a forgotten
dose.
4 Possible side effects
Like all medicines, Zofran suppositories can cause side
effects, although not everybody gets them.
Allergic reactions
If you have an allergic reaction, stop using it and see a
doctor straight away. The signs may include:
• sudden wheezing and chest pain or chest tightness
• swelling of your eyelids, face, lips, mouth or tongue
• skin rash - red spots or lumps under your skin (hives)
anywhere on your body
• collapse.
Other side effects include:
Very common (affects more than 1 in 10 people)
• headache.
Common (affects less than 1 in 10 people)
• a feeling of warmth or flushing
• constipation
• changes to liver function test results (if you use Zofran
suppositories with a medicine called cisplatin, otherwise
this side effect is uncommon).
Uncommon (affects less than 1 in 100 people)
• hiccups
• low blood pressure, which can make you feel faint or
dizzy
• uneven heart beat
• chest pain
• fits
• unusual body movements or shaking.
Rare (affects less than 1 in 1,000 people)
• feeling dizzy or light headed
• blurred vision
• disturbance in heart rhythm (sometimes causing a sudden
loss of consciousness).
Very rare (affects less than 1 in 10,000 people)
• poor vision or temporary loss of eyesight, which usually
comes back within 20 minutes.
If any of the side effects gets serious, or if you notice any
side effects not listed in this leaflet, please tell your doctor,
nurse or pharmacist.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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