Zylet Side Effects

Generic Name: loteprednol / tobramycin ophthalmic

Note: This page contains side effects data for the generic drug loteprednol / tobramycin ophthalmic. It is possible that some of the dosage forms included below may not apply to the brand name Zylet.

It is possible that some side effects of Zylet may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to loteprednol / tobramycin ophthalmic: ophthalmic suspension

As well as its needed effects, loteprednol / tobramycin ophthalmic may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking loteprednol / tobramycin ophthalmic, check with your doctor immediately:

More common
  • Blurred vision
  • change in vision
  • feeling like something is in the eye
  • increased intraocular pressure
  • loss of vision
  • pain or irritation of the clear front part of the eye
  • sensitivity of the eyes to light
Less common
  • Blurred vision or seeing blue-green halos around objects
  • decreased vision
  • difficulty seeing at night
  • discharge from the eye
  • dry eyes
  • eyelid burning, redness, itching, pain, or tenderness
  • fast heartbeat
  • fever
  • hives
  • hoarseness
  • irritation and swelling of the eye
  • itching
  • joint pain
  • lid itching and swelling
  • pain in the eye
  • rash
  • redness of the eyelid
  • redness of the skin
  • shortness of breath
  • stiffness or swelling
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • wheezing
Incidence not known
  • Redness of the eye
  • tearing

Some loteprednol / tobramycin ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Burning of the eye
  • headache
  • increased sensitivity of the eyes to light
  • stinging of the eye

For Healthcare Professionals

Applies to loteprednol / tobramycin ophthalmic: ophthalmic suspension

Ocular

Randomized studies involving patients treated with loteprednol etabonate therapy for 28 days or longer revealed the incidence of significant elevation in intraocular pressure (10 mmHg or greater) was 2% (15/901) with loteprednol etabonate, 7% (11/164) with 1% prednisolone acetate, and 0.5% (3/583) with placebo.

Very common (10% or more): Injection (about 20%), superficial punctate keratitis (about 15%), increased intraocular pressure (10%); Loteprednol ophthalmic (5% to 15%): Abnormal vision/blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, photophobia
Common (1% to 10%): Burning and stinging upon instillation (9%); Less than 4%: Vision disorders, discharge, itching, lacrimation disorder, photophobia, corneal deposits, ocular discomfort, eyelid disorder, other unspecified eye disorders; Loteprednol ophthalmic (less than 5%): Conjunctivitis, corneal abnormalities, eyelid erythema, keratoconjunctivitis, ocular irritation/pain/discomfort, papillae, uveitis; Tobramycin ophthalmic (less than 4%): Localized ocular toxicity including eyelid itching and swelling, conjunctival erythema
Frequency not reported: Secondary infections (including fungal infections of the cornea, bacterial ocular infections); Ophthalmic steroids: Elevated intraocular pressure (may be associated with infrequent optic nerve damage), visual acuity and field defects, posterior subcapsular cataract formation, delayed wound healing and secondary ocular infections from pathogens including herpes simplex, perforation of the globe where there is thinning of the cornea or sclera, acute anterior uveitis, keratitis, conjunctivitis, corneal ulcers, mydriasis, conjunctival hyperemia, loss of accommodation, ptosis

Nervous system

Very common (10% or more): Headache (about 14%)

Other

Common (1% to 10%): Other (unspecified) non-ocular side effects (less than 5%)

Hypersensitivity

Common (1% to 10%): Tobramycin ophthalmic: Hypersensitivity (less than 4%)
Rare (less than 0.1%): Tobramycin ophthalmic: Allergic conjunctivitis and blepharitis (at least 1 case)

A case of allergic conjunctivitis and blepharitis associated with tobramycin ophthalmic ointment has been reported. Hypersensitivity was confirmed by patch testing.

Respiratory

Very common (10% or more): Loteprednol ophthalmic: Rhinitis (less than 15%), pharyngitis (less than 15%)

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