Zetia Side Effects
Generic name: ezetimibe
Note: This document contains side effect information about ezetimibe. Some of the dosage forms listed on this page may not apply to the brand name Zetia.
Some side effects of Zetia may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to ezetimibe: oral tablet
Get emergency medical help if you have any of these signs of an allergic reaction while taking ezetimibe (the active ingredient contained in Zetia) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
unusual muscle weakness, tenderness, or pain;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate); or
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.
Less serious side effects of ezetimibe may include:
numbness or tingly feeling;
mild stomach pain, diarrhea;
runny or stuffy nose, cold symptoms;
joint pain, back pain; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to ezetimibe: oral tablet
General side effects including fatigue (2.2%) have been reported.
Gastrointestinal side effects including diarrhea (3.7%) and abdominal pain (3.0%) have been reported. Pancreatitis and nausea have also been reported in postmarketing experience.
A case of ezetimibe-induced acute pancreatitis occurred two weeks after initiating therapy. Following discontinuation of ezetimibe the patient's symptoms resolved and pancreatic enzyme levels normalized.
Immunologic side effects including sinusitis (3.6%), pharyngitis (2.3%), and viral infection (2.2%) have been reported.
Musculoskeletal side effects including back pain (4.1%) and arthralgia (3.8%) have been reported. Other effects including myalgia, arthralgia, elevated creatine phosphokinase, and rare reports of myopathy/rhabdomyolysis have been reported in postmarketing experience.
Respiratory side effects including coughing (2.3%) have been reported.
Hypersensitivity reactions including angioedema, anaphylaxis, rash, urticaria, and erythema multiforme have been reported in postmarketing experience.
Hepatic side effects including elevations in liver transaminases, hepatitis, cholelithiasis, and cholecystitis have been reported in postmarketing experience.
Hematologic side effects including thrombocytopenia have been reported in postmarketing experience.
Nervous system side effects including dizziness, paresthesia, and headache have been associated with ezetimibe (the active ingredient contained in Zetia) in postmarketing experience.
Psychiatric side effects including depression have been reported during the postmarketing experience.
More Zetia resources
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.