Is Zetia a statin drug/medication?
Can you take Zetia with a statin?
No, Zetia is not a statin drug.
Zetia reduces blood cholesterol in a different way than statin medications. Zetia lowers cholesterol levels by decreasing the amount of cholesterol that is absorbed from the small intestine so that there is less intestinal cholesterol delivered to the liver.
Can you take Zetia with a statin?
Yes, you can take Zetia with a statin unless you have active liver disease or if you are pregnant or breastfeeding a baby. Zetia and statins have a complementary effect on reducing cholesterol levels. They are both cholesterol-lowering medications that work in two distinctly different ways.
- Zetia acts in the small intestine to block cholesterol being absorbed so there is less cholesterol delivered to the liver, resulting in lower cholesterol levels. This causes an increase in hepatic LDL (low-density lipoprotein) receptor activity, which leads to increased clearance of LDL cholesterol.
- Statins reduce cholesterol levels by inhibiting an enzyme (called HMG-CoA reductase) which causes a decrease in the amount of cholesterol and lipoproteins that the body produces. Statin medications also increase the LDL receptors on liver cells, which increases the amount of LDL-cholesterol that can be absorbed out of the bloodstream, and then the LDL-cholesterol is broken down
Bottom line:
- Zetia is not a statin medication, it is a cholesterol absorption inhibitor.
- Zetia and statins are both cholesterol-lowering medications.
- Zetia and statins can be taken together except if you have active liver disease or if you are pregnant or breastfeeding a baby.
References
- Zetia Medication Information: https://www.drugs.com/pro/zetia.html
- Cholesterol absorption inhibitors: https://www.drugs.com/drug-class/cholesterol-absorption-inhibitors.html
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Drug information
- Zetia Information for Consumers
- Zetia prescribing info & package insert (for Health Professionals)
- Side Effects of Zetia (detailed)
Related support groups
- Zetia (18 questions, 33 members)