Zazole Side Effects

Generic Name: terconazole topical

Note: This page contains side effects data for the generic drug terconazole topical. It is possible that some of the dosage forms included below may not apply to the brand name Zazole.

It is possible that some side effects of Zazole may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to terconazole topical: vaginal cream, vaginal suppository

As well as its needed effects, terconazole topical (the active ingredient contained in Zazole) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking terconazole topical, check with your doctor immediately:

More common
  • Burning feeling in the vagina
Less common
  • Chills
  • fever
  • itching or irritation in the vagina
Incidence not known
  • Blistering, peeling, or loosening of the skin
  • chills
  • cough
  • diarrhea
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • fever
  • general feeling of discomfort or illness
  • headache
  • hives or welts
  • hoarseness
  • irritation
  • itching
  • joint or muscle pain
  • joint pain, stiffness or swelling
  • loss of appetite
  • muscle aches and pains
  • nausea
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • redness of the skin
  • runny nose
  • shivering
  • skin rash
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • sweating
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • trouble sleeping
  • troubled breathing
  • unusual tiredness or weakness
  • vomiting

Some terconazole topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Cramps
  • headache
  • heavy bleeding
  • pain
Less common
  • Abdominal or stomach pain
  • body pain
Incidence not known
  • Difficulty with moving
  • lack or loss of strength
  • muscle aching or cramping
  • muscle pain or stiffness
  • swollen joints

For Healthcare Professionals

Applies to terconazole topical: vaginal cream, vaginal suppository

Local

The suppository formulation was discontinued most often due to burning (2.5%) and pruritus (1.8%).

Common (1% to 10%): Local genitourinary side effects (including burning [up to 15.2%], irritation [3.1%], itching/pruritus [2.3%])
Frequency not reported: Pain, rash

Genitourinary

Common (1% to 10%): Dysmenorrhea (6%), vulvovaginal burning (5.2%), genital burning and itching (5%), pain of the female genitalia (4.2%), vulvovaginal itching

The cream formulations were discontinued most often due to vulvovaginal itching (up to 0.7%).

Nervous system

Very common (10% or more): Headache (up to 30.3%)
Postmarketing reports: Dizziness

Other

Common (1% to 10%): Body pain (up to 3.9%), fever (up to 2.8%), chills (up to 1.8%)
Rare (less than 0.1%): Influenza-like syndrome (consisting of fever, chills, nausea, dizziness)
Postmarketing reports: Asthenia, influenza-like illness (consisting of multiple reactions including fever and chills, nausea, vomiting, myalgia, arthralgia, malaise)

Gastrointestinal

Common (1% to 10%): Abdominal pain (3.4%)

Dermatologic

Photosensitivity reactions were reported after repeated dermal application of terconazole 2% and 0.8% creams under conditions of filtered artificial ultraviolet light. During US and foreign clinical trials, photosensitivity reactions were not reported in patients who were treated with terconazole suppositories or vaginal cream (0.4% and 0.8%).

Frequency not reported: Photosensitivity reactions
Postmarketing reports: Rash, toxic epidermal necrolysis, urticaria

Hypersensitivity

Postmarketing reports: Hypersensitivity, anaphylaxis, face edema

Hematologic

At least 1 patient developed leukocytosis and dyspnea.

Rare (less than 0.1%): Leukocytosis (at least 1 case)

Respiratory

Rare (less than 0.1%): Dyspnea (at least 1 case)
Postmarketing reports: Bronchospasm

At least 1 patient developed leukocytosis and dyspnea.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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