Zazole Side Effects

Generic name: terconazole topical

Medically reviewed by Drugs.com. Last updated on Oct 18, 2023.

Note: This document contains side effect information about terconazole topical. Some dosage forms listed on this page may not apply to the brand name Zazole.

Applies to terconazole topical: vaginal cream, vaginal suppository.

Serious side effects of Zazole

Along with its needed effects, terconazole topical (the active ingredient contained in Zazole) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking terconazole topical:

More common

Burning feeling in the vagina

Less common

Chills
fever
itching or irritation in the vagina

Incidence not known

Blistering, peeling, or loosening of the skin
chills
cough
diarrhea
difficulty with swallowing
dizziness
fast heartbeat
fever
general feeling of discomfort or illness
headache
hives or welts
hoarseness
irritation
itching
joint or muscle pain
joint pain, stiffness or swelling
loss of appetite
muscle aches and pains
nausea
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
rash
red skin lesions, often with a purple center
red, irritated eyes
redness of the skin
runny nose
shivering
skin rash
sore throat
sores, ulcers, or white spots in the mouth or on the lips
sweating
swelling of the eyelids, face, lips, hands, or feet
tightness in the chest
trouble sleeping
troubled breathing
unusual tiredness or weakness
vomiting

Other side effects of Zazole

Some side effects of terconazole topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Cramps
headache
heavy bleeding
pain

Less common

Abdominal or stomach pain
body pain

Incidence not known

Difficulty with moving
lack or loss of strength
muscle aching or cramping
muscle pain or stiffness
swollen joints

For Healthcare Professionals

Applies to terconazole topical: vaginal cream, vaginal suppository.

Nervous system

Very common (10% or more): Headache (up to 30.3%)

Postmarketing reports: Dizziness^[Ref]

Headache was reported in 26%, 21%, and 30.3% of patients using the 0.4% vaginal cream, 0.8% vaginal cream, and vaginal suppositories, respectively. In clinical trials with the suppository, headache occurred in up to 20.7% of patients given placebo.^[Ref]

Local

Frequency nor reported: Pain, rash

Vaginal suppositories:

-Very common (10% or more): Burning (15.2%)

-Common (1% to 10%): Pruritus^[Ref]

The suppository formulation was discontinued most often due to burning and pruritus.^[Ref]

Genitourinary

Vaginal cream 0.4%:

-Frequency not reported: Vulvovaginal burning/itching/irritation

Vaginal cream 0.8%:

-Common (1% to 10%): Dysmenorrhea, genital burning and itching

-Frequency not reported: Vulvovaginal itching

Vaginal suppositories:

-Common (1% to 10%): Pain of the female genitalia^[Ref]

The cream formulations were discontinued most often due to vulvovaginal itching.^[Ref]

Other

Frequency not reported: Influenza-like illness (consisting of fever, chills, nausea, dizziness)

Postmarketing reports: Asthenia, influenza-like illness (consisting of multiple reactions including fever, chills, nausea, vomiting, myalgia, arthralgia, malaise), face edema

Vaginal cream 0.4%

-Common (1% to 10%): Body pain, fever

-Uncommon (0.1% to 1%): Chills

Vaginal cream 0.8%

-Uncommon (0.1% to 1%): Fever

Vaginal suppositories

-Common (1% to 10%): Body pain, fever, chills^[Ref]

Gastrointestinal

Vaginal cream 0.8%:

-Common (1% to 10%): Abdominal pain^[Ref]

Hypersensitivity

Postmarketing reports: Hypersensitivity, anaphylaxis^[Ref]

Dermatologic

Frequency not reported: Photosensitivity reactions

Postmarketing reports: Rash, toxic epidermal necrolysis, urticaria^[Ref]

Photosensitivity reactions were reported after repeated dermal application of 2% and 0.8% cream formulations under conditions of filtered artificial ultraviolet light. During US and foreign clinical trials, photosensitivity reactions were not reported in patients who were treated with the suppositories or vaginal cream (0.4% and 0.8%).^[Ref]