Zavesca Side Effects
Generic name: miglustat
Note: This document contains side effect information about miglustat. Some of the dosage forms listed on this page may not apply to the brand name Zavesca.
Some side effects of Zavesca may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to miglustat: oral capsule
Nerve problems such as numbness, tingling, and tremor (shaking) of the hands have been reported by some people taking miglustat (the active ingredient contained in Zavesca) Contact your doctor immediately if you experience new or worsening numbness, tingling, or burning in the hands, arms, legs, or feet or tremor in the hands.
Seek emergency medical attention if you experience a rare but serious allergic reaction to miglustat including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives.
Other less serious side effects may be more likely to occur. Continue to take miglustat and talk to your doctor if you experience:
decreased appetite or weight loss;
gas or abdominal pain;
muscle cramps or weakness;
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to miglustat: oral capsule
Osmotic diarrhea appears to be the result of the disaccharidase inhibitory activity of miglustat (the active ingredient contained in Zavesca)
Gastrointestinal side effects have included diarrhea (67% to 89%), flatulence (29% to 70%), abdominal pain (18% to 50%), nausea (14% to 35%), vomiting (30% to 33%), dysphagia (20% to 25%), and abdominal distension (20%). Epigastric pain not food-related, dyspepsia, dry mouth, constipation, anorexia, and bloating have also been reported.
Nervous system side effects have included headache (30% to 45%), tremors (30% to 40%), gait abnormal (33%), exacerbation of existing tremor (25% to 30%), gait spastic (25%), ataxia (25%), hyperreflexia (25%), and paresthesia (20%). Dizziness, cramps in legs, unsteady gait, and migraine have also been reported.
Metabolic side effects including weight decrease has been reported in 25% to 65% of patients.
Ocular side effects have included visual disturbances.
Hematologic side effects have included thrombocytopenia.
Genitourinary side effects have included menstrual disorder in the female patient.
General side effects have included abdominal distension (20%), abdominal distension with gas, generalized weakness, back pain, and heaviness in limbs.
Respiratory side effects have included nasopharyngitis (33% to 35%), cough 33%, and sinusitis (25%).
Psychiatric side effects have included insomnia (30%), decreased appetite (25%), and depression (20%).
Other side effects have included fatigue (35% to 42%) and lacerations (20%).
More Zavesca resources
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