Zavesca Dosage

Generic name: miglustat
Dosage form: capsule

This dosage information does not include all the information needed to use Zavesca safely and effectively. See full prescribing information for Zavesca.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Instructions for Administration

Therapy should be directed by physicians who are knowledgeable in the management of Gaucher disease.

The recommended dose for the treatment of adult patients with type 1 Gaucher disease is one 100 mg capsule administered orally three times a day at regular intervals.

It may be necessary to reduce the dose to one 100 mg capsule once or twice a day in some patients for adverse effects, such as diarrhea or tremor.

Patients with Renal Insufficiency

In patients with mild renal impairment (adjusted creatinine clearance 50-70 mL/min/1.73 m2), ZAVESCA administration should commence at a dose of 100 mg twice per day. In patients with moderate renal impairment (adjusted creatinine clearance of 30-50 mL/min/1.73 m2), ZAVESCA administration should commence at a dose of one 100mg capsule per day. Use of ZAVESCA in patients with severe renal impairment (creatinine clearance of <30 mL/min/1.73 m2) is not recommended.

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