Generic name: miglustat
Dosage form: capsule
This dosage information does not include all the information needed to use Zavesca safely and effectively. See full prescribing information for Zavesca.
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Instructions for Administration
Therapy should be directed by physicians who are knowledgeable in the management of Gaucher disease.
The recommended dose for the treatment of adult patients with type 1 Gaucher disease is one 100 mg capsule administered orally three times a day at regular intervals.
It may be necessary to reduce the dose to one 100 mg capsule once or twice a day in some patients for adverse effects, such as diarrhea or tremor.
Patients with Renal Insufficiency
In patients with mild renal impairment (adjusted creatinine clearance 50-70 mL/min/1.73 m2), ZAVESCA administration should commence at a dose of 100 mg twice per day. In patients with moderate renal impairment (adjusted creatinine clearance of 30-50 mL/min/1.73 m2), ZAVESCA administration should commence at a dose of one 100mg capsule per day. Use of ZAVESCA in patients with severe renal impairment (creatinine clearance of <30 mL/min/1.73 m2) is not recommended.