Vismodegib Side Effects

Some side effects of vismodegib may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to vismodegib: oral capsule

Along with its needed effects, vismodegib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vismodegib:

Less common
  • Bloody or cloudy urine
  • coma
  • confusion
  • convulsions
  • decreased urine output
  • dizziness
  • dry mouth
  • fast or irregular heartbeat
  • headache
  • increased thirst
  • muscle pain or cramps
  • nausea or vomiting
  • pain in the lower back or side
  • shortness of breath
  • swelling of the face, ankles, or hands
  • thirst
  • unusual tiredness or weakness

Some side effects of vismodegib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Absent, missed, or irregular menstrual periods
  • change in taste
  • decreased appetite
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • hair loss or thinning of the hair
  • loss of taste
  • muscle spasm or stiffness
  • pain in the joints
  • stopping of menstrual bleeding
  • weight loss

For Healthcare Professionals

Applies to vismodegib: oral capsule

Dermatologic

Dermatologic side effects have included alopecia (63.8%).

Gastrointestinal

Gastrointestinal side effects have included nausea (30.4%), diarrhea (29.0%), constipation (21.0%), and vomiting (13.8%).

General

General side effects have included fatigue (39.9%).

Genitourinary

Genitourinary side effects have included amenorrhea.

Metabolic

Metabolic side effects have included decreased appetite (25.4%) and weight loss (44.9%).

Laboratory abnormalities (Grade 3 or greater) have included hyponatremia (4%), azotemia (2%), and hypokalemia (1%).

Musculoskeletal

Musculoskeletal side effects have included muscle spasms (71.7%), and arthralgia (15.9%).

Nervous system

Nervous system side effects have included dysgeusia (55.1%), and ageusia (10.9%).

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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