Vismodegib Side Effects

It is possible that some side effects of vismodegib may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to vismodegib: oral capsule

As well as its needed effects, vismodegib may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking vismodegib, check with your doctor immediately:

Less common
  • Bloody or cloudy urine
  • coma
  • confusion
  • convulsions
  • decreased urine output
  • dizziness
  • dry mouth
  • fast or irregular heartbeat
  • headache
  • increased thirst
  • muscle pain or cramps
  • nausea or vomiting
  • pain in the lower back or side
  • shortness of breath
  • swelling of the face, ankles, or hands
  • thirst
  • unusual tiredness or weakness

Some vismodegib side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Absent, missed, or irregular menstrual periods
  • change in taste
  • decreased appetite
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • hair loss or thinning of the hair
  • loss of taste
  • muscle spasm or stiffness
  • pain in the joints
  • stopping of menstrual bleeding
  • weight loss

For Healthcare Professionals

Applies to vismodegib: oral capsule

Dermatologic

Very common (10% or more): Alopecia (63.8%), pruritus
Common (1% to 10%): Rash, madarosis, abnormal hair growth[Ref]

Gastrointestinal

Very common (10% or more): Nausea (30.4%), diarrhea (29.0%), constipation (21.0%), vomiting (13.8%)
Common (1% to 10%): Dyspepsia, upper abdominal pain, abdominal pain[Ref]

General

The most frequent adverse drug reactions reported were muscle spasms (74.6%), alopecia (65.2%), dysgeusia (57.2%), weight loss (48.6%), fatigue (44.9%), and nausea (34.8%).[Ref]

Genitourinary

Very common (10% or more): Amenorrhea[Ref]

Metabolic

Very common (10% or more): Weight loss (44.9%), decreased appetite (25.4%)
Common (1% to 10%): Dehydration, hyponatremia, azotemia, and hypokalemia[Ref]

Musculoskeletal

Very common (10% or more): Muscle spasms (71.7%), arthralgia (15.9%)
Common (1% to 10%): Pain in extremity, back pain, musculoskeletal chest pain, myalgia, flank pain, musculoskeletal pain[Ref]

Nervous system

Very common (10% or more): Dysgeusia (55.1%), ageusia (10.9%)
Common (1% to 10%): Hypogeusia[Ref]

Hepatic

Common (1% to 10%): Hepatic enzymes increased[Ref]

Other

Very common (10% or more): Fatigue (39.9%)
Common (1% to 10%): Pain, asthenia[Ref]

Renal

Common (1% to 10%): Elevated blood urea nitrogen[Ref]

References

1. "Product Information. Erivedge (vismodegib)." Genentech, South San Francisco, CA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web1)