Vismodegib Side Effects

Some side effects of vismodegib may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to vismodegib: oral capsule

Get emergency medical help if you have any of these signs of an allergic reaction while taking vismodegib: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you miss a menstrual period. This could be a side effect, or it may be a sign that you are pregnant.

Less serious side effects of vismodegib may include:

• nausea, vomiting, decreased appetite;

• diarrhea, constipation;

• tired feeling;

• joint pain, muscle spasms;

• hair loss;

• weight loss;

• unusual or unpleasant taste in your mouth; or

• decreased sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to vismodegib: oral capsule

Dermatologic

Dermatologic side effects have included alopecia (63.8%).

Gastrointestinal

Gastrointestinal side effects have included nausea (30.4%), diarrhea (29.0%), constipation (21.0%), and vomiting (13.8%).

General

General side effects have included fatigue (39.9%).

Genitourinary

Genitourinary side effects have included amenorrhea.

Metabolic

Metabolic side effects have included decreased appetite (25.4%) and weight loss (44.9%).

Laboratory abnormalities (Grade 3 or greater) have included hyponatremia (4%), azotemia (2%), and hypokalemia (1%).

Musculoskeletal

Musculoskeletal side effects have included muscle spasms (71.7%), and arthralgia (15.9%).

Nervous system

Nervous system side effects have included dysgeusia (55.1%), and ageusia (10.9%).

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