Velosef Side Effects

Generic name: cephradine

Medically reviewed by Drugs.com. Last updated on Feb 9, 2023.

Note: This document contains side effect information about cephradine. Some dosage forms listed on this page may not apply to the brand name Velosef.

Applies to cephradine: oral capsule, oral powder for reconstitution.

Get emergency medical help if you have any of these signs of an allergic reaction while taking cephradine (the active ingredient contained in Velosef) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• diarrhea that is watery or bloody;

• fever, chills, body aches, flu symptoms;

• tightness in your chest;

• unusual bleeding;

• seizure (convulsions);

• pale or yellowed skin, dark colored urine, fever, confusion or weakness;

• jaundice (yellowing of the skin or eyes);

• skin rash, bruising, severe tingling, numbness, pain, muscle weakness;

• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or

• increased thirst, loss of appetite, swelling, weight gain, feeling short of breath, urinating less than usual or not at all.

Less serious side effects of cephradine may include:

• nausea, vomiting, stomach pain, mild diarrhea;

• stiff or tight muscles;

• joint pain;

• dizziness;

• feeling restless or hyperactive;

• unusual or unpleasant taste in your mouth;

• mild itching or skin rash; or

• vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

For Healthcare Professionals

Applies to cephradine: oral capsule, oral powder for reconstitution.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, and diarrhea, and are among the most common side effects associated with cephradine (the active ingredient contained in Velosef) Several cases of pseudomembranous colitis associated with the use of cephradine have been reported.^[Ref]

Pseudomembranous colitis has been reported in patients receiving cephradine both orally and intravenously. Diarrhea generally starts 1 to 16 days after starting cephradine therapy. If the diarrhea is unresponsive to discontinuation of the drug and/or standard therapy, a diagnosis of pseudomembranous colitis should be considered.^[Ref]

Hypersensitivity

Hypersensitivity reactions have included rash, urticaria, pruritus, and joint pain.^[Ref]

Hematologic

Hematologic side effects have included transient and mild eosinophilia, neutropenia and leukopenia.^[Ref]

Hepatic

Hepatic side effects have included transient elevations of SGOT, SGPT, and bilirubin. Hepatocellular damage has not been reported.^[Ref]

Renal

Renal side effects associated with some cephalosporins have included interstitial nephritis. (Reversible fever, azotemia, pyuria, and eosinophilia are the hallmarks of cephalosporin-induced interstitial nephritis.)^[Ref]

Genitourinary

Genitourinary side effects have included vaginal yeast infections.^[Ref]

Nervous system

Nervous system side effects have included dizziness.^[Ref]

Other

Other side effects have included chest tightness.^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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