Skip to Content

Vaprisol Side Effects

Generic Name: conivaptan

Note: This page contains side effects data for the generic drug conivaptan. It is possible that some of the dosage forms included below may not apply to the brand name Vaprisol.

For the Consumer

Applies to conivaptan: intravenous solution

As well as its needed effects, conivaptan (the active ingredient contained in Vaprisol) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking conivaptan, check with your doctor or nurse immediately:

More common:
  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at site
  • bloating or swelling of face, arms, hands, lower legs, ankles, or feet
  • blurred vision
  • decreased urine
  • dizziness
  • dry mouth
  • headache
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • nervousness
  • numbness or tingling in hands, feet, or lips
  • pounding in the ears
  • rapid weight gain
  • seizures
  • shortness of breath
  • slow or fast heartbeat
  • tingling of hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss
Less common:
  • Abdominal pain
  • bladder pain
  • bloody or cloudy urine
  • bluish color
  • change in consciousness
  • changes in skin color
  • chest pain
  • cold sweats
  • confusion
  • cool pale skin
  • cough
  • decreased urination
  • depression
  • difficult, burning, or painful urination
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • drowsiness
  • fainting
  • fear
  • fever or chills
  • flushed, dry skin
  • frequent urge to urinate
  • fruit-like breath odor
  • increase in amount of urine
  • increase in heart rate
  • increased hunger
  • increased urination
  • loss of consciousness
  • lower back or side pain
  • mental changes
  • muscle spasms [tetany] or twitching
  • nightmares
  • pale skin
  • problems in urination
  • rapid breathing
  • shakiness
  • sleeplessness
  • slurred speech
  • sneezing
  • sore mouth or tongue
  • sore throat
  • sunken eyes
  • sweating
  • swelling of foot or leg
  • tenderness
  • thirst
  • tightness in chest
  • trembling
  • trouble sleeping
  • troubled breathing with exertion
  • unable to sleep
  • unusual bleeding or bruising
  • wheezing
  • white patches in mouth and/or on tongue
  • wrinkled skin

Severity: Minor

Some conivaptan side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Diarrhea
Less common:
  • Difficulty having a bowel movement (stool)
  • flushing
  • redness of skin
  • unusually warm skin

For Healthcare Professionals

Applies to conivaptan: intravenous solution


Local side effects have included injection site reactions including erythema, pain, phlebitis, swelling, and cannulae site reactions.[Ref]


Gastrointestinal side effects have included constipation, diarrhea, dry mouth, nausea, vomiting, oral candidiasis, and thirst.[Ref]


Cardiovascular side effects have included atrial fibrillation, orthostatic hypotension, hypotension, peripheral edema, and hypertension.[Ref]


Metabolic side effects have included dehydration, hypokalemia, hypomagnesemia, and hyponatremia.[Ref]


Hematologic side effects have included anemia.[Ref]


Renal side effects have included hematuria, polyuria, and, pollakiuria.[Ref]


Genitourinary side effects have included urinary tract infection.[Ref]

Nervous system

Nervous system side effects have included headache.[Ref]


Psychiatric side effects have included insomnia and confusion.[Ref]


General side effects have included pain and pyrexia.[Ref]


Endocrine side effects have included hypoglycemia and hyperglycemia.[Ref]


1. "Product Information. Vaprisol (conivaptan)." Astellas Pharma US, Inc, Deerfield, IL.

It is possible that some side effects of Vaprisol may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.