Tygacil Side Effects

Generic Name: tigecycline

Please note - some side effects for Tygacil may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Tygacil - for the Consumer

Tygacil

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Tygacil:

Diarrhea; dizziness; increased sweating; nausea; pain, swelling, or redness at the injection site; stomach upset; vomiting; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; fast or slow heartbeat; fever, chills, or sore throat; severe or persistent diarrhea; severe or persistent nausea and vomiting; stomach pain; swollen, tender stomach; unusual vaginal itching or discharge; yellowing of the skin or eyes.

Tygacil Side Effects - for the Professional

Tygacil

The most common adverse reactions (incidence >5%) are nausea, vomiting, diarrhea, abdominal pain, headache, and increased SGPT. (6.1)

Side Effects by Body System

General

In phase 3 clinical trials (n=1415), 5% of patients discontinued tigecycline due to adverse events (compared to 5.3% for vancomycin/aztreonam and 4.4% for imipenem-cilastatin).

Gastrointestinal

Gastrointestinal side effects have included nausea (up to 35%), vomiting (up to 20%), diarrhea (12.7%), constipation (2.8%), dyspepsia (2.9%), anorexia, dry mouth, abnormal stools, and taste perversion. In postmarketing experience acute pancreatitis has been reported.

Cardiovascular

Cardiovascular side effects have included hypertension, hypotension, phlebitis, thrombophlebitis, bradycardia, tachycardia, and vasodilatation.

Hematologic

Hematologic side effects have included thrombocythemia (6.1%), anemia (4.2%), leukocytosis (3.7%), prolonged activated partial thromboplastin time (aPTT), prolonged prothrombin time (PT), eosinophilia, increased international normalized ratio (INR), and thrombocytopenia.

Hypersensitivity

Hypersensitivity reactions have included anaphylaxis and anaphylactoid reactions in postmarketing experience.

Dermatologic

Dermatologic side effects have included pruritus, rash, and sweating. Diffuse cutaneous hyperpigmentation has also been reported.

Genitourinary

Genitourinary side effects have included vaginal moniliasis, vaginitis, and leukorrhea.

Hepatic

Hepatic side effects have included jaundice. Hyperbilirubinemia, hepatic cholestasis, increased liver enzymes, and jaundice have been reported during postmarketing experience.

Local

Local side effects have included pain, inflammation, reaction, phlebitis, and edema at the injection site.

Metabolic

Metabolic side effects have included increased alkaline phosphatase, increased amylase, bilirubinemia, increased BUN, abnormal healing, hyperglycemia, hypokalemia, hypoproteinemia, increased lactic dehydrogenase, peripheral edema, increased SGOT and SGPT, increased creatinine, hypocalcemia, hypoglycemia, and hyponatremia.

Nervous system

Nervous system side effects have included dizziness, insomnia, and somnolence.

Respiratory

Respiratory system side effects have included increased cough, dyspnea, and pulmonary changes.

Other

Other side effects have included abdominal pain, abscess, asthenia, back pain, fever, headache, infections, pain, local reaction to procedure, sepsis/septic shock, wound infections, allergic reaction, and chills.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.