Tigecycline Pregnancy and Breastfeeding Warnings

Tigecycline is also known as: Tygacil

Tigecycline Pregnancy Warnings

Tigecycline has been assigned to pregnancy category D by the FDA. Animal studies have revealed slight fetal weight reductions, an increased incidence of delayed bone ossification, and an increased incidence of fetal loss at maternotoxic doses. There are no controlled data in human pregnancy. When used during tooth development (second half of pregnancy) tigecycline may cause permanent yellow-gray-brown discoloration of the teeth and enamel hypoplasia. It should not be administered during tooth development unless there are no other alternatives. Tigecycline should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Women who become pregnant during treatment should be advised of the potential hazard to the fetus.

Tigecycline Breastfeeding Warnings

There are no data on the excretion of tigecycline into human milk. It is readily excreted into rat milk; however, due to its limited oral bioavailability, minimal or no systemic exposure occurred in pups. Caution is recommended if tigecycline is administered to a breast-feeding woman.

See Also...

• tigecycline Consumer Information
• Pregnancy Support Group
• FDA Pregnancy Categories
• Medicine use during Pregnancy
• Medicine use while Breastfeeding
• Safe Medications during Breastfeeding

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