Treprostinil Side Effects
Some side effects of treprostinil may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to treprostinil: inhalation solution
Other dosage forms:
Along with its needed effects, treprostinil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking treprostinil:More common
- feeling of warmth
- redness of the face, neck, arms and occasionally, upper chest
- sore throat
- Bloody nose
- chest pain
- coughing or spitting up blood
- difficulty in breathing or troubled breathing
- fever or chills
- tightness in the chest
Get emergency help immediately if any of the following symptoms of overdose occur while taking treprostinil:Symptoms of overdose
- Blurred vision
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
- unusual tiredness or weakness
Some side effects of treprostinil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Abdominal or stomach cramps, discomfort or pain
- back pain
- loss of appetite
- muscle, jaw, or bone pain
- swollen mouth and tongue
- unpleasant taste
- urge to have bowel movement
For Healthcare Professionals
Applies to treprostinil: inhalation solution, injectable solution
In general, the most common adverse effects have included infusion site pain and reactions.
Local adverse effects have included infusion site pain (85%) and infusion site reactions (83%) such as erythema, induration, or rash. These effects were classified as severe in 39% and 38% of patients, respectively.
Gastrointestinal side effects have included diarrhea (25%), nausea (22%), and vomiting.
Nervous system side effects have included headache (27%), dizziness (9%), and insomnia.
Cardiovascular side effects have included vasodilatation (11%), edema (9%), hypotension (4%), bradycardia, syncope, and flushing. Postmarketing reports include angioedema.
Dermatologic reactions have included rash (14%) and pruritus (8%). Postmarketing reports have included angioedema.
Musculoskeletal side effects have included jaw pain (13%) and foot pain.
Complications associated with infusion systems were related to the pump (93%) or to the infusion set (7%). Side effects were reported in 8 patients (4 treprostinil and 4 placebo), including nausea (due to excess drug) and dyspnea (due to return of pulmonary arterial hypertension symptoms).
The following adverse events may be attributable to the IV mode of infusion including arm swelling, paresthesias, hematoma and pain. Using an indwelling central venous catheter to deliver chronic intravenous infusions of treprostinil is associated with the risk of blood stream infections and sepsis, which may be fatal.
Other side effects during a chronic dosing study include anorexia, vomiting, infusion site infection, asthenia, and abdominal pain.
Respiratory side effects of inhaled treprostinil have included cough, throat irritation, and pharyngolaryngeal pain.
More about treprostinil
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