Syprine Side Effects
Generic Name: trientine
Note: This page contains side effects data for the generic drug trientine. It is possible that some of the dosage forms included below may not apply to the brand name Syprine.
It is possible that some side effects of Syprine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to trientine: oral capsule
As well as its needed effects, trientine (the active ingredient contained in Syprine) may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking trientine, check with your doctor or nurse as soon as possible:More common - Symptoms of anemia
- Unusually pale skin
- unusual tiredness
- general feeling of discomfort, illness, or weakness
- joint pain
- skin rash, blisters, hives, or itching
- swollen glands
Note: Signs of anemia are more likely to occur in children, menstruating women, and pregnant women, who usually need more iron than other patients. If these signs appear during trientine treatment, your doctor will need to do some tests.
For Healthcare Professionals
Applies to trientine: oral capsule
Central nervous system side effects have included dystonia, malaise, myasthenia gravis, and weakness.[Ref]
Immunologic side effects have included systemic lupus erythematosus.
Hematologic side effects have included iron deficiency and hypochromic microytic anemia. The hypochromic microytic anemia was reported in 4 patients being treated with trientine (the active ingredient contained in Syprine) who had primary biliary cirrhosis.
Musculoskeletal system side effects have included muscle spasm, muscle pain, cramps, and rhabdomyolysis. The rhabdomyolysis was reported in 4 patients being treated with trientine (the active ingredient contained in Syprine) who had primary biliary cirrhosis.
Gastrointestinal side effects have included heartburn, epigastric pain and tenderness, acute gastritis, aphthoid ulcers, abdominal pain, melena, and anorexia. These side effects were reported in 4 patients being treated with trientine (the active ingredient contained in Syprine) who had primary biliary cirrhosis.
Dermatologic side effects have included thickening, fissuring, and flaking of the skin. These side effects were reported in 4 patients being treated with trientine (the active ingredient contained in Syprine) who had primary biliary cirrhosis.
1. "Product Information. Syprine (trientine)." Aton Pharma, Lawrenceville, NJ.
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