Synvisc-One Side Effects
Generic name: hylan g-f 20
Medically reviewed by Drugs.com. Last updated on Jun 4, 2023.
Note: This document contains side effect information about hylan g-f 20. Some dosage forms listed on this page may not apply to the brand name Synvisc-One.
Applies to hylan g-f 20: injection injectable, injection solution. Other dosage forms:
Serious side effects of Synvisc-One
Along with its needed effects, hylan g-f 20 (the active ingredient contained in Synvisc-One) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking hylan g-f 20:
Rare
- Difficulty breathing
- hives
- shortness of breath
Other side effects of Synvisc-One
Some side effects of hylan g-f 20 may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Knee pain
- pain at the injection site
- swelling of the knee
Rare
- Calf cramps
- dizziness
- facial flushing with swelling of the lips
- headache
- infection of the joint
- itching of the skin
- muscle pain
- nausea
- pain on one side of the body with anxiety, nausea, and tiredness
- rapid heartbeat
- skin rash
For Healthcare Professionals
Applies to hylan g-f 20: intra-articular solution.
Dermatologic
Frequency not reported: Rash, itching, hives, itching, face swelling, generalized urticaria[Ref]
Gastrointestinal
Frequency not reported: Hemorrhoids, nausea, tonsillitis[Ref]
Musculoskeletal
Frequency not reported: Low back sprain, calf cramps, muscle cramps
Postmarketing reports: Acute inflammation (e.g., joint pain, swelling, effusion, joint warmth and/or stiffness)[Ref]
Cardiovascular
Frequency not reported: Tachyarrhythmia, phlebitis with varicosities, flushing[Ref]
Nervous system
Frequency not reported: Headache, dizziness, chills, paresthesia[Ref]
Respiratory
Frequency not reported: Respiratory difficulty[Ref]
Hypersensitivity
Frequency not reported: Synovial eosinophilia[Ref]
Local
Postmarketing reports: Injection site pain, injection site swelling[Ref]
Hematologic
Rare (less than 0.1%): Thrombocytopenia[Ref]
Other
Frequency not reported: Ankle edema, fever, peripheral edema, malaise[Ref]
More about Synvisc-One (hylan g-f 20)
- Check interactions
- Compare alternatives
- Reviews (173)
- Dosage information
- During pregnancy
- Drug class: viscosupplementation agents
- En español
Patient resources
Other formulations
Related treatment guides
References
1. Product Information. Synvisc (hylan G-F 20). Wyeth-Ayerst Laboratories. PROD.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.