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Synvisc-One Side Effects

Generic Name: hylan g-f 20

Note: This page contains side effects data for the generic drug hylan g-f 20. It is possible that some of the dosage forms included below may not apply to the brand name Synvisc-One.

For the Consumer

Applies to hylan g-f 20: injection injectable, injection solution

As well as its needed effects, hylan g-f 20 (the active ingredient contained in Synvisc-One) may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking hylan g-f 20, check with your doctor or nurse as soon as possible:

  • Difficulty breathing
  • hives
  • shortness of breath

Severity: Minor

Some hylan g-f 20 side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Knee pain
  • pain at the injection site
  • swelling of the knee
  • Calf cramps
  • dizziness
  • facial flushing with swelling of the lips
  • headache
  • infection of the joint
  • itching of the skin
  • muscle pain
  • nausea
  • pain on one side of the body with anxiety, nausea, and tiredness
  • rapid heartbeat
  • skin rash

For Healthcare Professionals

Applies to hylan g-f 20: intra-articular solution


A retrospective study reported pain, warmth, and swelling after 11% of injections, in some cases lasting up to 3 weeks.[Ref]

In clinical trials with 511 patients who received a total of 1771 injections, knee pain and/or swelling were reported in 7.2% patients or 2.2% of injections and were the most common adverse reactions.[Ref]


Dermatologic side effects have included individual cases of rash, itching, generalized urticaria, recurring small hives, facial flush with lip swelling, and body prickling. These symptoms did not reoccur upon rechallenge.[Ref]


Gastrointestinal side effects have included nausea and hemorrhoids.[Ref]


Musculoskeletal side effects have included calf cramps, ankle edema, muscle pain, low back sprain, and pseudosepsis.[Ref]

Pseudosepsis has been characterized as severe joint inflammation with pain and effusion occurring 24 to 72 hours after injection and it may be more likely to occur after the second or third injection or with repeated courses. Nonsteroidal anti-inflammatory drugs, intra-articular steroids, and/or arthrocentesis are often required to treat pseudosepsis.[Ref]


Cardiovascular side effects have included tachyarrhythmia and phlebitis with varicosities.[Ref]

Nervous system

Nervous system side effects have included anxiety and listlessness, dizziness, headache, shivering, and body pain.[Ref]


Respiratory side effects have included respiratory difficulties.[Ref]


Metabolic side effects have included one case report of pseudogout and one of acute gout in a patient with no prior episodes.[Ref]


Hypersensitivity reactions have included one reported case of a suspected allergic reaction with fever, large effusion in the knee, and synovial eosinophilia.[Ref]


Local reactions have included acute painful joint effusions after injection into the knee in 1% to 11% of patients.[Ref]


1. "Product Information. Synvisc (viscoelastic solution)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

2. Isomoto H, Saenko VA, Kanazawa Y, et al. "Enhanced Expression of Interleukin-8 and Activation of Nuclear Factor Kappa-B in Endoscopy-negative Gastroesophageal Reflux Disease." Am J Gastroenterol 99 (2004): 589-97

3. Yacyshyn EA, Matteson EL "Gout after intraarticular injection of hylan GF-20 (Synvisc) [letter]." J Rheumatol 26 (1999): 2717

4. Allen E, Krohn K "Adverse reaction to Hylan GF-20." J Rheumatol 27 (2000): 1572

5. Pullman-Mooar S, Mooar P, Sieck M, Clayburne G, Schumacher HR "Are there distinctive inflammatory flares after hylan g-f 20 intraarticular injections?" J Rheumatol 29 (2002): 2611-4

6. Puttick MP, Wade JP, Chalmers A, Connell DG, Rangno KK "Acute local reactions after intraarticular hylan for osteoarthritis of the knee [see comments." J Rheumatol 22 (1995): 1311-4

It is possible that some side effects of Synvisc-One may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.