Synagis Side Effects
Generic Name: palivizumab
Note: This document contains side effect information about palivizumab. Some of the dosage forms listed on this page may not apply to the brand name Synagis.
Some side effects of Synagis may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to palivizumab: intramuscular powder for solution, intramuscular solution
Along with its needed effects, palivizumab (the active ingredient contained in Synagis) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking palivizumab:More common
- Bluish color of the fingernails, lips, skin, palms, or nail beds
- blurred vision
- difficulty with breathing
- difficulty with swallowing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast heartbeat
- hives or welts
- irregular, fast or slow, or shallow breathing
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of strength or energy
- muscle pain or weakness
- redness of the skin
- shortness of breath
- skin rash
- tightness in the chest
- unusual tiredness or weakness
- Black, tarry stools
- bleeding gums
- blood in the urine or stools
- pinpoint red spots on the skin
- unusual bleeding or bruising
Some side effects of palivizumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Incidence not known
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
For Healthcare Professionals
Applies to palivizumab: intramuscular powder for injection, intramuscular solution
Most of the reported adverse reactions documented are derived from studies of the drug in the pediatric patient. These have included anaphylaxis, acute hypersensitivity reactions, upper respiratory infection, otitis media, fever, rhinitis, hernia, and SGOT elevation.
Cardiovascular side effects have included arrhythmia during studies of congenital heart disease patients.
Gastrointestinal side effects have included mild nausea, moderate vomiting, and diarrhea.
Hematologic side effects have included mild eosinophilia and thrombocytopenia. Severe thrombocytopenia (platelet count less than 50,000/microliter) has been reported during postmarketing experience.
Hypersensitivity side effects have included severe acute hypersensitivity reactions and anaphylaxis (including dyspnea, cyanosis, respiratory failure, urticaria, pruritus, angioedema, hypotonia, and unresponsiveness) during postmarketing experience.
Local side effects have included injection site reactions during postmarketing experience.
Other side effects have included cyanosis during studies of congenital heart disease patients.
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