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Synagis Side Effects

Generic Name: palivizumab

Note: This page contains side effects data for the generic drug palivizumab. It is possible that some of the dosage forms included below may not apply to the brand name Synagis.

In Summary

Common side effects of Synagis include: rhinitis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to palivizumab: intramuscular powder for solution, intramuscular solution

As well as its needed effects, palivizumab (the active ingredient contained in Synagis) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking palivizumab, check with your doctor or nurse immediately:

More common:
  • Bluish color of the fingernails, lips, skin, palms, or nail beds
  • blurred vision
  • confusion
  • cough
  • difficulty with breathing
  • difficulty with swallowing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast heartbeat
  • fever
  • hives or welts
  • irregular, fast or slow, or shallow breathing
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of strength or energy
  • muscle pain or weakness
  • redness of the skin
  • shortness of breath
  • skin rash
  • sweating
  • tightness in the chest
  • unresponsiveness
  • unusual tiredness or weakness
  • wheezing
Incidence not known:
  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • pinpoint red spots on the skin
  • unusual bleeding or bruising

Severity: Minor

Some palivizumab side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known:
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For Healthcare Professionals

Applies to palivizumab: intramuscular powder for injection, intramuscular solution

Cardiovascular

Frequency not reported: Arrhythmia (during studies of congenital heart disease patients)[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, diarrhea[Ref]

Hypersensitivity

Frequency not reported: Anaphylaxis, anaphylactic shock (sometimes fatal)
Postmarketing reports: Angioedema[Ref]

Local

Common (1% to 10%): Injection site reactions[Ref]

Other

Very common (10% or more): Pyrexia[Ref]

Dermatologic

Very common (10% or more): Rash
Uncommon (0.1% to 1%): Urticaria
Frequency not reported: Pruritus[Ref]

General

The most serious adverse reactions are anaphylaxis and other acute hypersensitivity reactions.[Ref]

Hematologic

Uncommon (0.1% to 1%): Thrombocytopenia (mild), eosinophilia (mild)
Postmarketing reports: Severe thrombocytopenia (platelet count less than 50,000/microliter)[Ref]

Nervous system

Uncommon (0.1% to 1%): Convulsions[Ref]

Respiratory

Frequency not reported: Cyanosis during studies of congenital heart disease patients
Postmarketing reports: Dyspnea, asthma, bronchospasm[Ref]

References

1. "Product Information. Synagis (palivizumab)." Ross Product Division Pharmaceuticals, Columbus, OH.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Boeckh M, Berrey MM, Bowden RA, Crawford SW, Balsley J, Corey L "Phase 1 evaluation of the respiratory syncytial virus-specific monoclonal antibody palivizumab in recipients of hematopoietic stem cell transplants." J Infect Dis 184 (2001): 350-4

4. Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online. Available from: URL: http://www.appco.com.au/appguide/default.asp." ([2006]):

It is possible that some side effects of Synagis may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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