Sustiva Side Effects

Generic Name: efavirenz

Note: This page contains side effects data for the generic drug efavirenz. It is possible that some of the dosage forms included below may not apply to the brand name Sustiva.

It is possible that some side effects of Sustiva may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to efavirenz: oral capsule, oral tablet

As well as its needed effects, efavirenz (the active ingredient contained in Sustiva) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking efavirenz, check with your doctor immediately:

More common
  • Depression
  • skin rash or itching
Less common
  • Blood in the urine
  • difficult or painful urination
  • pain in the lower back or side
Rare
  • Abdominal or stomach pain
  • blistering
  • changes in vision
  • clumsiness or unsteadiness
  • confusion
  • convulsions (seizures)
  • cough
  • dark urine
  • delusions
  • double vision
  • fainting
  • fast or pounding heartbeat
  • fever or chills
  • headache (severe and throbbing)
  • hives
  • inappropriate behavior
  • loss of appetite
  • mood or mental changes (severe)
  • muscle cramps or pain
  • nausea or vomiting
  • nerve pain
  • open sores
  • pain, tenderness, bluish color, or swelling of the leg or foot
  • rapid weight gain
  • seeing, hearing, or feeling things that are not there
  • sense of constant movement of self or surroundings
  • sores, ulcers, or white spots in the mouth or on the lips
  • speech disorder
  • swelling or tenderness in the upper abdominal or stomach area
  • swelling of the hands, arms, feet, or legs
  • thoughts of suicide or attempts at suicide
  • tightness in the chest
  • tingling, burning, numbness, or pain in the hands, arms, feet, or legs
  • tingling, burning, or prickling sensations
  • tremor
  • troubled breathing
  • unusual tiredness
  • weight loss
  • yellow eyes or skin
Incidence not known
  • Actions that are out of control
  • attack, assault, or force
  • continuing vomiting
  • delusions of persecution, mistrust, suspiciousness, or combativeness
  • difficult or labored breathing
  • early appearance of redness or swelling of the skin
  • general feeling of tiredness or weakness
  • irritability
  • late appearance of rash with or without weeping blisters that become crusted, especially in sun-exposed areas of the skin, may extend to unexposed areas
  • light-colored stools
  • nervousness
  • talking, feeling, and acting with excitement

Some efavirenz side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Diarrhea
  • dizziness
  • drowsiness
  • headache
  • increased sweating
  • poor concentration
  • trouble sleeping
Less common or rare
  • Abnormally decreased sensitivity, particularly to touch
  • agitation or anxiety
  • belching
  • change in sense of taste or smell
  • dry mouth
  • excessive gas
  • false sense of well-being
  • flaking and falling off of the skin
  • flushing
  • general feeling of discomfort
  • heartburn
  • indigestion
  • joint pain
  • lack of feeling or emotion
  • loss of hair
  • loss of memory
  • loss of sense of reality
  • mood changes
  • pain
  • painful, red, hot, or irritated hair follicles
  • ringing in the ears
  • stomach discomfort
  • unusual dreams
  • weakness
Incidence not known
  • Difficulty having a bowel movement (stool)
  • discoloration of the fingernails or toenails
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • increased amount of fat in the upper back and neck, or around the chest and stomach area
  • lose fat from the legs, arms, and face
  • sensation of spinning
  • swelling of the breasts or breast soreness in both females and males

For Healthcare Professionals

Applies to efavirenz: oral capsule, oral tablet

General

The most significant side effects included nervous system symptoms, psychiatric symptoms, and rash. The most common side effects (at least moderate severity) were impaired concentration, abnormal dreams, rash, dizziness, nausea, headache, fatigue, insomnia, and vomiting in patients using this drug in combination with lamivudine-zidovudine or indinavir.

Administration of this drug with food may increase drug exposure and may increase the rate of side effects (especially nervous system symptoms).[Ref]

Metabolic

Increased nonfasting serum cholesterol and HDL have been reported; clinical significance unknown.

Increased nonfasting triglycerides (at least 751 mg/dL) and glucose (greater than 250 mg/dL) have been reported in up to 11% and up to 5% of patients, respectively.[Ref]

Very common (10% or more): Increased nonfasting serum cholesterol (up to 54%), increased HDL (up to 35%), increased nonfasting triglycerides (up to 11%)
Common (1% to 10%): Increased glucose, anorexia, hypertriglyceridemia, decreased weight (included cachexia/wasting), weight gain, weight loss
Uncommon (0.1% to 1%): Hypercholesterolemia
Frequency not reported: Redistribution/accumulation of body fat (including central obesity, dorsocervical fat enlargement, peripheral wasting, facial wasting, breast enlargement, "cushingoid appearance"), insulin resistance, hyperglycemia, hyperlactatemia, alcohol intolerance, increased appetite[Ref]

Nervous system

Nervous system symptoms generally began the first or second day of therapy and often resolved after 2 to 4 weeks. Nervous system symptoms of any grade and regardless of causality (52.7%) included dizziness, insomnia, impaired concentration, somnolence, abnormal dreams, hallucinations, amnesia, agitation, euphoria, depersonalization, confusion, abnormal thinking, and stupor during clinical trials with this drug in combination with other antiretroviral agents. These symptoms were mild in 33.3%, moderate in 17.4%, and severe in 2% of patients. Therapy was discontinued in 2.1% of patients due to these side effects.

Side effects of moderate or severe intensity included dizziness (up to 9%), headache (up to 8%), impaired concentration (up to 5%), and somnolence (up to 2%).

Vacuolar axonopathy and hypersomnolence leading to coma and death was reported in a patient with elevated drug levels.[Ref]

Very common (10% or more): Dizziness (included lightheadedness/fainting; up to 28.1%)
Common (1% to 10%): Impaired concentration, headache, somnolence, disturbance in attention, paresthesia (included numbness/tingling)
Uncommon (0.1% to 1%): Agitation, amnesia, ataxia, abnormal coordination, convulsions, abnormal thinking, vertigo, taste perversion
Frequency not reported: Depersonalization, confusion, stupor, impaired attention span, impaired coordination, migraine headaches, neuralgia, peripheral neuropathy, speech disorder, parosmia, vacuolar axonopathy and hypersomnolence leading to coma and death
Postmarketing reports: Cerebellar coordination and balance disturbances, hypoesthesia, neuropathy, tremor, tinnitus[Ref]

Dermatologic

Rashes were usually mild-to-moderate maculopapular skin eruptions. The median time to onset of rash in adults was 11 days. In most patients, the rash resolved within 1 month despite continued use of the drug. Treatment was discontinued in 1.7% of patients due to rash.

There was limited experience using this drug in patients who previously discontinued other nonnucleoside reverse transcriptase inhibitors due to rash. In 19 such patients formerly on nevirapine, about half developed a mild to moderate rash; 2 of those patients discontinued therapy because of the rash.[Ref]

Very common (10% or more): Skin rash of any grade (26.3%), rash (included erythema multiforme, rash, erythematous rash, follicular rash, maculopapular rash, petechial rash, pustular rash, urticaria, macules, papules, erythema, redness, inflammation, allergic rash, welts, hives, itchy, pruritus; up to 16%), grade 2 rash (diffuse maculopapular rash, dry desquamation; 14.7%), grade 1 rash (erythema, pruritus; 10.7%)
Common (1% to 10%): Pruritus, increased sweating, urticaria (included allergic rash/welts/hives), erythema/redness/inflammation, blisters/ulcerations/lesions, dry skin
Uncommon (0.1% to 1%): Grade 3 rash (vesiculation, moist desquamation, ulceration), grade 4 rash (erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, necrosis requiring surgery, exfoliative dermatitis)
Frequency not reported: Nail disorders, skin discoloration, leukocytoclastic vasculitis
Postmarketing reports: Erythema multiforme, photoallergic dermatitis, Stevens-Johnson syndrome[Ref]

Psychiatric

Psychiatric symptoms generally began the first or second day of therapy and often resolved after 2 to 4 weeks. Patients with history of psychiatric disorders were at greater risk of serious psychiatric side effects. Psychiatric side effects classified as serious during controlled trials included severe depression, suicidal ideation, nonfatal suicide attempts, aggressive behavior, paranoid reactions, and manic reactions. One percent of patients discontinued or interrupted therapy due to at least 1 of these side effects.

Side effects of moderate or severe intensity included insomnia (up to 7%), depression (up to 5%), anxiety (up to 4%), abnormal dreams (up to 3%), and nervousness (up to 2%).[Ref]

Very common (10% or more): Depression (up to 19%), insomnia (included dreams/sleeping problems; up to 16.3%), anxiety (up to 13%)
Common (1% to 10%): Nervousness (included agitation/hyperactive), abnormal dreams, severe depression, hallucinations
Uncommon (0.1% to 1%): Affect lability, confusional state, euphoric mood, suicidal ideation, nonfatal suicide attempts, aggressive behavior, paranoid reactions, manic reactions, drug abuse
Frequency not reported: Obsessive disorder, irritability, mood changes, vivid dreams, nightmares, delirium, increased libido, decreased libido, aggravated depression, apathy
Postmarketing reports: Aggressive reactions, agitation, delusions, emotional lability, mania, neurosis, paranoia, psychosis, completed suicide, psychosis-like behavior[Ref]

Gastrointestinal

Elevated amylase (greater than 2 times the upper limit of normal [ULN]) has been reported in up to 6% of patients.

A 42-year-old HIV-positive woman's saquinavir in her highly active antiretroviral therapy was replaced with this drug to increase compliance. Two weeks after initiation, the patient reported severe and constant burning in her tongue, gums, and oral mucosa and was diagnosed with burning mouth syndrome (BMS). Efavirenz (the active ingredient contained in Sustiva) was discontinued and the BMS resolved within a week.[Ref]

Very common (10% or more): Diarrhea (up to 14%)
Common (1% to 10%): Nausea (included nausea/vomiting), vomiting, elevated amylase, dyspepsia, abdominal pain (included groin/pelvic pain), constipation
Uncommon (0.1% to 1%): Pancreatitis, flatulence
Frequency not reported: Asymptomatic increases in serum amylase levels, gastritis, gastroenteritis, gastroesophageal reflux, dry mouth, burning mouth syndrome
Postmarketing reports: Malabsorption[Ref]

Other

False-positive urine cannabinoid test results have been observed with some screening assays in uninfected and HIV-infected subjects using this drug.[Ref]

Very common (10% or more): Pain (included flank and back pain; up to 13%)
Common (1% to 10%): Fatigue (included asthenia, malaise), edema (included enlarged/swollen, leg edema, peripheral edema), fever
Uncommon (0.1% to 1%): Asthenia
Frequency not reported: False-positive urine cannabinoid test results, vitamin D deficiency, hot flushes, malaise, influenza-like symptoms, peripheral edema, syncope
Postmarketing reports: Flushing, contraceptive failure (with an implantable hormonal contraceptive)[Ref]

Hepatic

Common (1% to 10%): Increased ALT, increased AST, increased GGT
Frequency not reported: Acute hepatitis
Postmarketing reports: Hepatic failure (a few reports were characterized by a fulminant course, with some cases progressing to transplantation or death), hepatic enzyme increase, hepatitis[Ref]

Increased ALT, AST, and GGT to greater than 5 times ULN have each been reported in up to 8% of patients. Isolated elevations of GGT may have reflected enzyme induction not associated with liver toxicity.

During clinical trials, elevations in ALT and AST to greater than 5 times ULN occurred in 20% and 13%, respectively, of patients seropositive for hepatitis B and/or C. Therapy was discontinued in 3% of coinfected patients due to liver or biliary system disorders.

Some of the postmarketing reports of hepatic failure occurred in patients with no preexisting liver disease or other identifiable risk factors.[Ref]

Hematologic

Neutropenia (less than 750/mm3) was reported in up to 10% of patients.[Ref]

Common (1% to 10%): Neutropenia
Rare (less than 0.1%): Hemolytic anemia[Ref]

Cardiovascular

Common (1% to 10%): Cardiovascular dysfunction
Frequency not reported: QT interval prolongation, torsades de pointes, tachycardia, thrombophlebitis
Postmarketing reports: Palpitations[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity
Frequency not reported: Skin rash, eosinophilia, and systemic involvement (lymphadenopathy, interstitial nephritis, pneumonia, pulmonary infiltration, hepatitis, fever, rigor, myalgia, arthralgias)
Postmarketing reports: Allergic reactions[Ref]

Genitourinary

Analysis of a 3 mm stone, eliminated by a 47-year-old HIV-1-infected male patient, showed a stone consisting of 60% efavirenz (the active ingredient contained in Sustiva) metabolites.[Ref]

Uncommon (0.1% to 1%): Hematuria
Rare (less than 0.1%): Urolithiasis
Frequency not reported: Impotence
Postmarketing reports: Gynecomastia[Ref]

Respiratory

Uncommon (0.1% to 1%): Dyspnea
Frequency not reported: Asthma, sinusitis, upper respiratory tract infection[Ref]

Renal

Uncommon (0.1% to 1%): Renal calculus
Rare (less than 0.1%): Renal colic
Frequency not reported: Podocyte damage[Ref]

Ocular

Uncommon (0.1% to 1%): Blurred vision
Frequency not reported: Diplopia
Postmarketing reports: Abnormal vision[Ref]

Immunologic

Frequency not reported: Immune reconstitution/reactivation syndrome, autoimmune disorders in the setting of immune reconstitution (e.g., Graves' disease, polymyositis, Guillain-Barre syndrome)[Ref]

Musculoskeletal

Frequency not reported: Osteomalacia (due to drug-induced vitamin D deficiency), osteonecrosis
Postmarketing reports: Arthralgia, myalgia, myopathy[Ref]

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