Solaraze Side Effects
Generic name: diclofenac topical
Note: This document contains side effect information about diclofenac topical. Some of the dosage forms listed on this page may not apply to the brand name Solaraze.
Some side effects of Solaraze may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to diclofenac topical: topical gel/jelly, topical patch extended release, topical solution
Along with its needed effects, diclofenac topical (the active ingredient contained in Solaraze) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking diclofenac topical:More common
- Application site reactions, including skin rash; pain, tingling, or burning sensation
- flu-like syndrome (body ache, headache, fever, with or without chills)
- itching skin
- Application site reactions, including swelling; increased skin sensitivity; itching, redness, or pain caused by reaction from exposure to sun
- blood in the urine
- decrease in body movement
- dry, itching, or burning eyes
- eye pain
- headaches, including migraines
- high blood pressure
- increased sensitivity of the eyes to light
- nasal congestion
- pain or tenderness around the eyes and cheekbones
- redness or swelling of the eyes
- shortness of breath
- skin rash other than at the application site
- sore throat
- tightness in the chest
- troubled breathing
- ulcers or sores on the skin, other than at the application site
Some side effects of diclofenac topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Burning skin
- dry skin
- red skin
- scaly skin
- thickened skin
- tingling skin
- back pain
- bleeding skin
- chest pain
- joint pain
- lack or loss of strength
- loss or thinning of the hair
- muscle pain
- neck pain
- runny nose
- stomach upset or pain
For Healthcare Professionals
Applies to diclofenac topical: topical film extended release, topical gel, topical solution
Local application site reactions have been reported in 75% to 86% of patients and have included rash (35% to 36%), pruritus (31% to 52%), dry skin (25% to 27%), contact dermatitis (19% to 33%), pain (15% to 26%), paresthesia (8% to 20%), exfoliation (6% to 24%), vesiculobullous rash (4%), edema (3% to 4%), hyperesthesia (3%), photosensitivity reaction (3%), acne (1%), alopecia (1% to 2%), erythema (less than 1%), irritation (less than 1%), and papules (less than 1%).
The gel vehicle has also been associated with a high incidence of application site reactions (71% to 86%), including pruritus (45% to 59%), pain (22% to 30%), rash (17% to 20%), dry skin (12% to 17%), exfoliation (4% to 13%), and paresthesia (4% to 20%). Other local reactions have included skin carcinoma, hypertonia, lacrimation disorder, maculopapular rash, purpuric rash, skin hypertrophy, and vasodilation in less than 1% of patients.
Dermatologic side effects have included pruritus (4%), rash (2% to 4%), dry skin (3%), contact dermatitis (2%), pain (1% to 2%), skin carcinoma (2%), and skin ulcer (1% to 2%). Other dermatologic side effects have included skin hypertrophy, paresthesia, seborrhea, urticaria in less than 1% of patients, and skin discoloration. The gel vehicle has been associated with acne (1% to 2%), herpes simplex (2%), maculopapular rash (2%), and skin nodule (2%).
Cardiovascular side effects have included hypertension (1% to 2%), migraine (1%), and palpitation. The gel vehicle has been associated with phlebitis (2%).
Endocrine side effects have included hyperglycemia (greater than 1%).
Gastrointestinal side effects have included dyspepsia (2% to 3%), diarrhea (2%), abdominal pain (1% to 2%), dry mouth, gastroenteritis, mouth ulceration, nausea, rectal hemorrhage, and ulcerative stomatitis. The gel vehicle has been associated with constipation (2%).
Genitourinary side effects have included hematuria (2%).
Hepatic side effects have included elevations in serum transaminases in up to 15% of patients as well as rare cases of hepatitis, jaundice, and fatal fulminant hepatitis. Liver injury is most likely to occur in older females in the first 6 months of use.
Immunologic side effects have included infection and flu syndrome (greater than 1%).
Metabolic side effects have included increased creatine phosphokinase (4%), increased SGOT (3%), increased SGPT (2%), increased creatinine (2%), hypercholesterolemia (1%), hyperglycemia (1%), and creatinine increased. The gel vehicle has been associated with edema (2%).
Musculoskeletal side effects have included myalgia (2 to 3%), arthralgia (2%), arthrosis (2%), and leg cramps.
Nervous system side effects have included headache (7%), hypokinesia (2%), depression, dizziness, drowsiness, lethargy, paresthesia, and paresthesia at application site. The gel vehicle has been associated with dizziness (4%) and anxiety (1% to 2%).
Ocular side effects have included conjunctivitis (2 to 4%) eye pain (2%), blurred or abnormal vision, cataract, and eye disorder.
Respiratory side effects have included asthma, dyspnea, pharyngitis, pneumonia, rhinitis, and sinusitis in 2% of patients.
Renal side effects have included increased creatinine (2%).
Other side effects have included flu syndrome (1 to 10%), accidental injury (4%), infection (4%), back pain (2 to 4%), asthenia (2%), neck pain (2%), pain (2%), chest pain (1 to 2%), ear pain, and taste perversion.
More Solaraze resources
- Solaraze Prescribing Information (FDA)
- Solaraze topical Monograph (AHFS DI)
- Solaraze Topical Advanced Consumer (Micromedex) - Includes Dosage Information
- Solaraze gel MedFacts Consumer Leaflet (Wolters Kluwer)
- Pennsaid solution MedFacts Consumer Leaflet (Wolters Kluwer)
- Pennsaid Prescribing Information (FDA)
- Pennsaid Consumer Overview
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.