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Sitagliptin Side Effects

It is possible that some side effects of sitagliptin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to sitagliptin: oral tablet

As well as its needed effects, sitagliptin may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking sitagliptin, check with your doctor immediately:

Less common
  • Anxiety
  • blurred vision
  • chills
  • cold sweats
  • confusion
  • cool, pale skin
  • depression
  • dizziness
  • fast heartbeat
  • headache
  • increased hunger
  • loss of consciousness
  • nausea
  • nervousness
  • nightmares
  • seizures
  • shakiness
  • slurred speech
  • unusual tiredness or weakness

Some sitagliptin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Body aches or pain
  • cough
  • difficulty with breathing
  • ear congestion
  • fever
  • loss of voice
  • muscle aches
  • sneezing
  • sore throat
  • stuffy or runny nose
Less common
  • Abdominal or stomach pain
  • diarrhea

For Healthcare Professionals

Applies to sitagliptin: oral tablet


Metabolic side effects have included hypoglycemia.[Ref]


Gastrointestinal side effects have included abdominal pain, nausea, and diarrhea. Postmarketing experience has included constipation, vomiting, acute pancreatitis, including fatal and nonfatal hemorrhagic and necrotizing pancreatitis.[Ref]


Respiratory side effects have included nasopharyngitis and upper respiratory tract infection.[Ref]

Nervous system

Nervous system side effects have included headache.[Ref]


Hypersensitivity side effects have included anaphylaxis, angioedema, and exfoliative skin conditions including Stevens-Johnson syndrome. Postmarketing hypersensitivity reactions have included rash, urticaria, and cutaneous vasculitis.


Hepatic side effects have included postmarketing reports of hepatic enzyme elevations.


Renal side effects have included postmarketing reports of worsening renal function, including acute renal failure, sometimes requiring dialysis.


Arthralgia, myalgia, pain in extremities, and back pain have been reported postmarketing.


1. "Product Information. Januvia (sitagliptin)." Merck & Company Inc, West Point, PA.

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