Sitagliptin Side Effects

Brand Names: Januvia

Please note - some side effects for Sitagliptin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Sitagliptin - for the Consumer

Sitagliptin

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Sitagliptin:

Diarrhea; headache; nausea; runny or stuffy nose; sore throat; upper respiratory infection; upset stomach.

Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); decreased urination; red, blistered, swollen, or peeling skin; symptoms of pancreas inflammation (eg, severe stomach or back pain with or without nausea or vomiting).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Sitagliptin/Metformin

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Sitagliptin/Metformin:

Diarrhea; gas; headache; indigestion; nausea; sore throat; stomach upset; stuffy or runny nose; vomiting; weakness.

Severe allergic reactions (rash; hives; itching; difficulty swallowing or breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); chest pain or discomfort; decreased urination; dizziness or light-headedness; fast or difficult breathing; feeling of being unusually cold; general feeling of being unwell; muscle pain or weakness; red, blistered, swollen, or peeling skin; slow or irregular heartbeat; symptoms of pancreas inflammation (eg, severe stomach or back pain with or without nausea or vomiting); unusual drowsiness; unusual or persistent stomach pain or discomfort; unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Sitagliptin/Simvastatin

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Sitagliptin/Simvastatin:

Constipation; diarrhea; headache; mild stomach pain; nausea; runny or stuffy nose; sore throat; upper respiratory tract infection.

Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); burning, numbness, or tingling; change in the amount of urine produced; dark or red-colored urine; decreased sexual ability; depression; dizziness; fast or irregular heartbeat; fever, chills, or persistent cough or sore throat; joint pain; memory problems; muscle pain, tenderness, or weakness (with or without fever and fatigue); red, swollen, blistered, or peeling skin; shortness of breath; swelling of the hands, legs, or feet; symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, severe or persistent nausea or stomach pain, yellowing of the skin or eyes); symptoms of pancreas inflammation (eg, severe stomach or back pain with or without nausea or vomiting); trouble sleeping; unusual bruising or bleeding; unusual tiredness or weakness; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Side Effects by Body System - for Healthcare Professionals

Metabolic

Metabolic side effects have included hypoglycemia.

Gastrointestinal

Gastrointestinal side effects have included abdominal pain, nausea, and diarrhea. Postmarketing experience has included constipation and vomiting.

Respiratory

Respiratory side effects have included nasopharyngitis and upper respiratory tract infection.

Nervous system

Nervous system side effects have included headache.

Hypersensitivity

Hypersensitivity side effects have included anaphylaxis, angioedema, and exfoliative skin conditions including Stevens-Johnson syndrome. Postmarketing hypersensitivity reactions have included cutaneous vasculitis, acute pancreatitis, including fatal and nonfatal hemorrhagic and necrotizing pancreatitis.

Hepatic

Hepatic side effects have included postmarketing reports of hepatic enzyme elevations.

Renal

Renal side effects have included postmarketing reports of worsening renal function, including acute renal failure, sometimes requiring dialysis.

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