Sitagliptin Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Diabetes Type 2

100 mg orally once daily.

Renal Dose Adjustments

moderate renal dysfunction (creatinine clearance 30 to 49 mL/minute): 50 mg orally once daily.
severe renal insufficiency (creatinine clearance 29 mL/minute or less) or end stage renal disease requiring hemodialysis or peritoneal dialysis: 25 mg orally once daily. The dose may be administered without regard to the timing of dialysis.

Liver Dose Adjustments

No dosage adjustment for is necessary for patients with mild or moderate hepatic insufficiency. There is no clinical experience in patients with severe hepatic insufficiency (Child-Pugh score greater than 9).

Precautions

Because there is a need for dosage adjustment based upon renal function, assessment of renal function is recommended prior to initiation of sitagliptin and periodically thereafter.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

End stage renal disease requiring hemodialysis or peritoneal dialysis: 25 mg orally once daily. The dose may be administered without regard to the timing of dialysis.

Other Comments

Sitagliptin may be taken without regard to meals.

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