Sabril Side Effects
Generic Name: vigabatrin
Note: This page contains side effects data for the generic drug vigabatrin. It is possible that some of the dosage forms included below may not apply to the brand name Sabril.
It is possible that some side effects of Sabril may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to vigabatrin: oral powder, oral powder for solution, oral tablet
As well as its needed effects, vigabatrin (the active ingredient contained in Sabril) may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking vigabatrin, check with your doctor immediately:More common
- Blue-yellow color blindness
- blurred vision
- decreased vision or other vision changes
- eye pain
- increase in seizures
- loss of memory
- problems with memory
- Uncontrolled rolling eye movements
Some vigabatrin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common
- Abdominal or stomach pain
- abnormal coordination
- burning, tingling, or prickly sensations
- double vision or seeing double
- increased movement
- joint pain
- mental depression
- sleepiness or unusual drowsiness
- trouble sitting still
- increased saliva
- muscle weakness
- poor concentration
- speech disorder
- thinking abnormal
- trouble sleeping
- weight gain
For Healthcare Professionals
Applies to vigabatrin: oral powder for reconstitution, oral tablet
General side effects including fatigue (up to 40%), gait disturbance (up to 12%), asthenia (up to 7%), peripheral edema (up to 7%), influenza (up to 7%), chest pain (up to 5%), malaise (up to 5%), contusion (up to 5%), wound secretion (up to 2%), thirst (up to 2%), developmental delay, facial edema, malignant hyperthermia, and multi-organ failure have been reported.
Nervous system side effects including headache (up to 33%), somnolence (up to 26%), dizziness (up to 26%), nystagmus (up to 19%), tremor (up to 16%), memory impairment (up to 16%), abnormal coordination (up to 16%), disturbance in attention (up to 9%), sensory disturbance (up to 7%), paraesthesia (up to 7%), lethargy (up to 7%), hypoesthesia (up to 5%), status epilepticus (up to 5%), sensory loss (up to 5%), hyporeflexia (up to 5%), hyperreflexia (up to 4%), sedation (up to 4%), dysarthria (2%), postictal state (up to 2%), dystonia, encephalopathy, hypertonia, hypotonia, and optic neuritis have been reported.
Psychiatric side effects including irritability (up to 23%), depression (up to 14%), confusional state (up to 14%), expressive language disorder (up to 7%), abnormal thinking (up to 7%), depressed mood (up to 5%), abnormal behavior (up to 5%), nervousness (up to 5%), abnormal dreams (up to 5%), anxiety (up to 4%), acute psychosis, apathy, delirium, hypomania, neonatal agitation, and psychotic disorder have been reported.
Gastrointestinal side effects including diarrhea (up to 16%), nausea (up to 10%), vomiting (up to 9%), constipation (up to 8%), upper abdominal pain (5%), dyspepsia (up to 5%), toothache (up to 5%), stomach discomfort (up to 4%), abdominal pain (up to 3%), abdominal distension (up to 2%), gastrointestinal hemorrhage, and esophagitis have been reported.
Ocular side effects including blurred vision (up to 16%), diplopia (up to 16%), eye pain (5%), asthenopia (2%), and changes in color vision have been reported.
Metabolic side effects including increased weight (up to 14%) and increased appetite (up to 5%) have been reported.
Respiratory side effects including nasopharyngitis (up to 14%), pharyngolaryngeal pain (up to 14%), cough (up to 14%), upper respiratory tract infection (up to 9%), sinus headache (up to 6%), pulmonary congestion (up to 5%), bronchitis (up to 5%), laryngeal edema, pulmonary embolism, respiratory failure, and stridor have been reported.
Musculoskeletal side effects including arthralgia (up to 10%), muscle twitching (up to 9%), back pain (up to 7%), pain in extremity (up to 6%), myalgia (up to 5%), muscle spasms (up to 3%), joint sprain (up to 2%), muscle strain (up to 2%), and myoclonus have been reported.
Genitourinary side effects including dysmenorrhea (up to 9%) and erectile dysfunction (up to 5%) have been reported.
Other side effects including vertigo (up to 5%), tinnitus (up to 2%), and deafness have been reported.
Dermatologic side effects including rash (up to 5%), angioedema, maculopapular rash, pruritus, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) have been reported.
Renal side effects including urinary tract infection (up to 5%) have been reported.
Endocrine side effects including delayed puberty have been reported.
Hepatic side effects including cholestasis have been reported.
More about Sabril (vigabatrin)
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