Rifaximin Side Effects

Some side effects of rifaximin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to rifaximin: oral tablet

Along with its needed effects, rifaximin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rifaximin:

More common
  • Black, tarry stools
  • dizziness or lightheadedness
  • muscle spasm
  • rapid breathing
  • shortness of breath
  • sleeplessness
  • trouble sleeping
  • unable to sleep
Less common
  • Blood in urine
  • bloody nose
  • chest pain
  • continuing ringing or buzzing or other unexplained noise in the ears
  • fainting
  • feeling of constant movement of self or surroundings
  • increased heart rate
  • sensation of spinning
  • sunken eyes
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Incidence not known
  • Cracks in the skin
  • hives or welts
  • itching skin
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of heat from the body
  • rash
  • red, swollen skin scaly skin
  • redness of skin

Some side effects of rifaximin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bloated
  • difficulty in moving
  • dizziness
  • excess air or gas in the stomach or intestines
  • fever
  • frequent urge to defecate
  • full feeling
  • headache
  • lower back or side pain
  • muscle pain or stiffness
  • pain in joints
  • passing gas
  • stomach pain
  • straining while passing stool
  • swelling of the hands, ankles, feet, or lower legs
Less common
  • Abnormal dreams
  • blurred vision
  • chills
  • confusion
  • cough
  • decreased urination
  • difficulty having a bowel movement (stool)
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry lips
  • dry mouth
  • ear pain
  • feeling of warmth
  • hearing loss
  • lightheadedness
  • loss of appetite
  • loss of taste
  • nausea
  • painful or difficult urination
  • pale skin
  • redness of the face, neck, arms and occasionally, upper chest
  • sore throat
  • sweating
  • swollen glands
  • thirst
  • vomiting
  • wrinkled skin

For Healthcare Professionals

Applies to rifaximin: oral tablet

Gastrointestinal

Gastrointestinal side effects have included nausea (up to 14%), flatulence (11%), abdominal pain (up to 9%), abdominal distension (up to 8%), rectal tenesmus (7%), upper abdominal pain (6%), defecation urgency (6%), constipation (up to 6%), stomach discomfort (less than 5%), and vomiting (2%). Lower abdominal pain, abdominal tenderness, dry mouth, and esophageal variceal bleed have been reported in greater than 2% but less than 5% of patients. Diarrhea, blood in stool, dry throat, dysentery, fecal abnormality, gingival disorder, inguinal hernia, and dry lips have been reported in less than 2% of patients. Straining and bad taste in mouth have also been reported. Clostridium difficile associated colitis has been reported during postmarketing experience.

Other

Other side effects have included peripheral edema (15%), fatigue (up to 12%), ascites (11%), back pain (6%), pyrexia (up to 6%), chest pain (less than 5%), and pain (less than 5%). Generalized edema, influenza-like illness, contusion, fall, and procedural pain have been reported in greater than 2% but less than 5% of patients. Ear pain, motion sickness, malaise, and hot flashes have been reported in less than 2% of patients.

Nervous system

Nervous system side effects have included dizziness (up to 13%) and headache (10%). Vertigo, amnesia, disturbance in attention, hypoesthesia, memory impairment, and tremor have been reported in greater than 2% but less than 5% of patients. Migraine, syncope, tinnitus, and loss of taste have been reported in less than 2% of patients.

Hypersensitivity

Hypersensitivity side effects have included exfoliative dermatitis, rash, angioneurotic edema (swelling of face and tongue and difficulty swallowing), urticaria, pruritus, flushing, and anaphylaxis during postmarketing experience and have occurred as early as within 15 minutes of rifaximin administration.

Dermatologic

Dermatologic side effects have included pruritus (up to 9%), rash (up to 5%), and cellulitis (greater than 2% but less than 5%). Clamminess, sunburn, and increased sweating have been reported in less than 2% of patients.

Musculoskeletal

Musculoskeletal side effects have included muscle spasms (up to 9%), arthralgia (up to 6%), myalgia (less than 5%), and pain in extremity (greater than 2% but less than 5%). Neck pain and weakness have been reported in less than 2% of patients.

Hematologic

Hematologic side effects have included anemia (8%). Lymphocytosis, monocytosis, and neutropenia have been reported in less than 2% of patients.

Respiratory

Respiratory side effects have included cough (7%), nasopharyngitis (up to 7%), dyspnea (up to 6%), upper respiratory tract infection (less than 5%), and rhinitis (less than 5%). Pneumonia and epistaxis have been reported in greater than 2% but less than 5% of patients. Respiratory tract infection, nasal passage irritation, pharyngitis, pharyngolaryngeal pain, and rhinorrhea have been reported in less than 2% of patients.

Psychiatric

Psychiatric side effects have included depression (7%), insomnia (up to 7%), confusional state (greater than 2% but less than 5%), and abnormal dreams (less than 2%).

Metabolic

Metabolic side effects have included increased weight (greater than 2% but less than 5%), anorexia (less than 5%), and dehydration (less than 5%). Hyperglycemia, hyperkalemia, hypoglycemia, and hyponatremia have been reported in greater than 2% but less than 5% of patients. Decreased weight has been reported in less than 2% of patients.

Genitourinary

Genitourinary side effects have included choluria, dysuria, hematuria, polyuria, proteinuria, urinary frequency, and blood in urine in less than 2% of patients.

Cardiovascular

Cardiovascular side effects have included hypotension (greater than 2% but less than 5%).

Hepatic

Hepatic side effects have included increased aspartate aminotransferase in less than 2% of patients.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web3)