Pegaspargase Side Effects

Some side effects of pegaspargase may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to pegaspargase: solution

Along with its needed effects, pegaspargase may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking pegaspargase:

More common
  • Abdominal or stomach pain
  • blurry vision
  • constipation
  • dry mouth and skin
  • faintness
  • fatigue
  • fruit-like breath odor
  • increased hunger or thirst
  • increased need to urinate
  • nausea
  • skin paleness
  • skin rash
  • sweating
  • troubled breathing
  • unexplained weight loss
  • unusual bleeding or bruising
  • vomiting
Less common
  • Bloating
  • chest pain
  • confusion
  • cough
  • darkened urine
  • difficulty in breathing or swallowing
  • dizziness
  • fast heartbeat
  • fever or chills
  • headache
  • hives or itching
  • indigestion
  • itching, especially of hands and feet
  • loss of appetite
  • numbness, tingling, or swelling in arms or legs
  • pains in stomach, side, or abdomen, possibly radiating to the back
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • reddening of the skin, especially around ears
  • shortness of breath
  • swelling of eyes, face, or inside of nose
  • tightness in chest
  • unusual tiredness or weakness (sudden and severe)
  • wheezing
  • yellow eyes or skin
Rare
  • Black, tarry stools
  • blood in urine
  • hoarseness
  • lower back or side pain
  • painful or difficult urination
  • pinpoint red spots on skin

Some side effects of pegaspargase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • General feeling of discomfort or illness
Less common
  • Anxiety
  • behavior change similar to drunkenness
  • blurred vision
  • cold sweats
  • convulsions (seizures)
  • cool pale skin
  • difficulty in concentrating
  • drowsiness
  • lack of appetite
  • nervousness
  • nightmares
  • pain at place of injection
  • pain in joints or muscles
  • restless sleep
  • shakiness
  • slurred speech

For Healthcare Professionals

Applies to pegaspargase: injectable solution

Hepatic

Hepatic side effects have been reported frequently. These have included chemical hepatotoxicities. Increased SGPT has been reported frequently. Bilirubinemia and increased SGOT have been reported occasionally.

Hematologic

Hematologic side effects have been reported the most frequently. These have included coagulopathies. Thrombosis (4%), leukopenia, pancytopenia, thrombocytopenia, decreased fibrinogen, increased thromboplastin, hyperuricemia, hypoproteinemia, and hemolytic anemia have been reported occasionally.

Gastrointestinal

Gastrointestinal side effects reported frequently have included nausea and vomiting. Clinical pancreatitis, anorexia, diarrhea, jaundice, and lip edema have also been reported occasionally.

Endocrine

Endocrine side effects have included hyperglycemia requiring insulin therapy (3%) and hypoglycemia.

Dermatologic

Dermatologic side effects have included rash, erythema, and urticaria.

Respiratory

Respiratory side effects have included dyspnea, cough, upper respiratory infections, and bronchospasm.

Cardiovascular

Cardiovascular side effects have included edema. Hypotension, disseminated intravascular coagulation, peripheral edema, and tachycardia, chest pain, and endocarditis have been reported occasionally.

General

General side effects reported frequently have included fever and malaise. Chills, night sweats, pain (general), pain in the extremities, and abdominal pain have also been reported.

Local

Local side effects have included injection site pain and injection site reaction.

Musculoskeletal

Musculoskeletal side effects have included arthralgia and myalgia.

Nervous system

Nervous system side effects have included convulsions, headaches, and paresthesia.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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