Pegaspargase Side Effects
Some side effects of pegaspargase may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to pegaspargase: solution
Along with its needed effects, pegaspargase may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking pegaspargase:More common
- Abdominal or stomach pain
- blurry vision
- dry mouth and skin
- fruit-like breath odor
- increased hunger or thirst
- increased need to urinate
- skin paleness
- skin rash
- troubled breathing
- unexplained weight loss
- unusual bleeding or bruising
- chest pain
- darkened urine
- difficulty in breathing or swallowing
- fast heartbeat
- fever or chills
- hives or itching
- itching, especially of hands and feet
- loss of appetite
- numbness, tingling, or swelling in arms or legs
- pains in stomach, side, or abdomen, possibly radiating to the back
- puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
- reddening of the skin, especially around ears
- shortness of breath
- swelling of eyes, face, or inside of nose
- tightness in chest
- unusual tiredness or weakness (sudden and severe)
- yellow eyes or skin
- Black, tarry stools
- blood in urine
- lower back or side pain
- painful or difficult urination
- pinpoint red spots on skin
Some side effects of pegaspargase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- General feeling of discomfort or illness
- behavior change similar to drunkenness
- blurred vision
- cold sweats
- convulsions (seizures)
- cool pale skin
- difficulty in concentrating
- lack of appetite
- pain at place of injection
- pain in joints or muscles
- restless sleep
- slurred speech
For Healthcare Professionals
Applies to pegaspargase: injectable solution
Hepatic side effects have been reported frequently. These have included chemical hepatotoxicities. Increased SGPT has been reported frequently. Bilirubinemia and increased SGOT have been reported occasionally.
Hematologic side effects have been reported the most frequently. These have included coagulopathies. Thrombosis (4%), leukopenia, pancytopenia, thrombocytopenia, decreased fibrinogen, increased thromboplastin, hyperuricemia, hypoproteinemia, and hemolytic anemia have been reported occasionally.
Gastrointestinal side effects reported frequently have included nausea and vomiting. Clinical pancreatitis, anorexia, diarrhea, jaundice, and lip edema have also been reported occasionally.
Endocrine side effects have included hyperglycemia requiring insulin therapy (3%) and hypoglycemia.
Dermatologic side effects have included rash, erythema, and urticaria.
Respiratory side effects have included dyspnea, cough, upper respiratory infections, and bronchospasm.
Cardiovascular side effects have included edema. Hypotension, disseminated intravascular coagulation, peripheral edema, and tachycardia, chest pain, and endocarditis have been reported occasionally.
General side effects reported frequently have included fever and malaise. Chills, night sweats, pain (general), pain in the extremities, and abdominal pain have also been reported.
Local side effects have included injection site pain and injection site reaction.
Musculoskeletal side effects have included arthralgia and myalgia.
Nervous system side effects have included convulsions, headaches, and paresthesia.
More pegaspargase resources
- pegaspargase Concise Consumer Information (Cerner Multum)
- pegaspargase MedFacts Consumer Leaflet (Wolters Kluwer)
- pegaspargase Intramuscular, Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information
- Pegaspargase Professional Patient Advice (Wolters Kluwer)
- Pegaspargase Monograph (AHFS DI)
- Oncaspar Prescribing Information (FDA)
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