Pegaspargase Side Effects

Brand Names: Oncaspar

Please note - some side effects for Pegaspargase may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Pegaspargase - for the Consumer

Pegaspargase

All medicines may cause side effects, but many people have no, or minor, side effects. No COMMON side effects have been reported with Pegaspargase . Seek medical attention right away if any of these SEVERE side effects occur when using Pegaspargase:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; trouble swallowing); blurred vision or other vision changes; calf or leg pain or swelling; chest pain; confusion; coughing up blood; dizziness; one-sided weakness; pain, redness, or swelling at the injection site; severe headache; shortness of breath; severe stomach pain; slurred speech; swelling of an arm or leg; symptoms of high blood sugar (eg, increased thirst, hunger, or urination; drowsiness; flushing; rapid breathing; fruit-like breath odor); unusual bleeding or bruising; yellowing of skin or eyes.

Side Effects by Body System

Hepatic

Hepatic side effects have been reported frequently. These have included chemical hepatotoxicities. Increased SGPT has been reported frequently. Bilirubinemia and increased SGOT have been reported occasionally.

Hematologic

Hematologic side effects have been reported the most frequently. These have included coagulopathies. Thrombosis (4%), leukopenia, pancytopenia, thrombocytopenia, decreased fibrinogen, increased thromboplastin, hyperuricemia, hypoproteinemia, and hemolytic anemia have been reported occasionally.

Gastrointestinal

Gastrointestinal side effects reported frequently have included nausea and vomiting. Clinical pancreatitis, anorexia, diarrhea, jaundice, and lip edema have also been reported occasionally.

Endocrine

Endocrine side effects have included hyperglycemia requiring insulin therapy (3%) and hypoglycemia.

Dermatologic

Dermatologic side effects have included rash, erythema, and urticaria.

Respiratory

Respiratory side effects have included dyspnea, cough, upper respiratory infections, and bronchospasm.

Cardiovascular

Cardiovascular side effects have included edema. Hypotension, disseminated intravascular coagulation, peripheral edema, and tachycardia, chest pain, and endocarditis have been reported occasionally.

General

General side effects reported frequently have included fever and malaise. Chills, night sweats, pain (general), pain in the extremities, and abdominal pain have also been reported.

Local

Local side effects have included injection site pain and injection site reaction.

Musculoskeletal

Musculoskeletal side effects have included arthralgia and myalgia.

Nervous system

Nervous system side effects have included convulsions, headaches, and paresthesia.

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