Patanol Side Effects

Generic Name: olopatadine ophthalmic

Note: This page contains side effects data for the generic drug olopatadine ophthalmic. It is possible that some of the dosage forms included below may not apply to the brand name Patanol.

It is possible that some side effects of Patanol may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to olopatadine ophthalmic: ophthalmic solution

Along with its needed effects, olopatadine ophthalmic (the active ingredient contained in Patanol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects of olopatadine ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Headache
  • runny or stuffy nose
  • sore throat
Less common
  • Back pain
  • burning, dryness, itching, or stinging of the eye
  • change in taste
  • chills
  • diarrhea
  • eye irritation or pain
  • feeling of something in the eye
  • general feeling of discomfort or illness
  • increased cough
  • loss of appetite
  • muscle aches and pains
  • nausea
  • pain
  • redness of eye or inside of eyelid
  • shivering
  • sweating
  • swelling of eyelid
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting

For Healthcare Professionals

Applies to olopatadine ophthalmic: ophthalmic solution


A small study reported that patients using olopatadine ophthalmic (the active ingredient contained in Patanol) experienced less discomfort upon instillation than those using ketotifen ophthalmic.

In general, topical olopatadine is well tolerated with a low incidence of adverse reactions. The most commonly reported side effect is headache, occurring in approximately 7% of patients.


Ocular side effects have frequently included blurred vision, burning or stinging, conjunctivits, dry eye, foreign body sensation, hyperemia, keratitis, lid edema, pain, and ocular pruritus.


Other side effects have frequently included symptoms similar to cold syndrome (10%), pharyngitis (10%), asthenia, back pain, flu syndrome, headache (7%), increased cough, and infection.


Gastrointestinal side effects have included nausea and taste perversion.


Respiratory side effects have included rhinitis and sinusitis.


Hypersensitivity side effects have included ocular hypersensitivity reaction.

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