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Pataday Side Effects

Generic Name: olopatadine ophthalmic

Note: This page contains side effects data for the generic drug olopatadine ophthalmic. It is possible that some of the dosage forms included below may not apply to the brand name Pataday.

It is possible that some side effects of Pataday may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to olopatadine ophthalmic: ophthalmic solution

As well as its needed effects, olopatadine ophthalmic (the active ingredient contained in Pataday) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking olopatadine ophthalmic, check with your doctor immediately:

Less common
  • Blurred vision
  • eye irritation or pain
  • swelling of the eyelid

Some olopatadine ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Headache
  • runny or stuffy nose
  • sore throat
Less common
  • Back pain
  • body aches or pain
  • burning, dryness, itching, or stinging of the eye
  • change in taste
  • chills
  • cough
  • diarrhea
  • feeling of something in the eye
  • general feeling of discomfort or illness
  • increased cough
  • lack or loss of strength
  • loss of appetite
  • muscle aches and pains
  • nausea
  • pain or tenderness around the eyes and cheekbones
  • redness of the eye or inside of the eyelid
  • sensitivity of the eyes to light
  • shivering
  • sneezing
  • sweating
  • tender, swollen glands in the neck
  • trouble sleeping
  • trouble swallowing
  • unusual tiredness or weakness
  • voice changes
  • vomiting

For Healthcare Professionals

Applies to olopatadine ophthalmic: ophthalmic solution


A small study reported that patients using olopatadine ophthalmic (the active ingredient contained in Pataday) experienced less discomfort upon instillation than those using ketotifen ophthalmic.[Ref]

In general, topical olopatadine is well tolerated with a low incidence of adverse reactions. The most commonly reported side effect is headache, occurring in approximately 7% of patients.[Ref]


Ocular side effects have frequently included blurred vision, burning or stinging, conjunctivits, dry eye, foreign body sensation, hyperemia, keratitis, lid edema, pain, and ocular pruritus.[Ref]


Other side effects have frequently included symptoms similar to cold syndrome (10%), pharyngitis (10%), asthenia, back pain, flu syndrome, headache (7%), increased cough, and infection.[Ref]


Gastrointestinal side effects have included nausea and taste perversion.


Respiratory side effects have included rhinitis and sinusitis.


Hypersensitivity side effects have included ocular hypersensitivity reaction.


1. "Product Information. Patanol (olopatadine ophthalmic)." Alcon Laboratories Inc, Fort Worth, TX.

2. Artal MN, Luna JD, Discepola M "A forced choice comfort study of olopatadine hydrochloride 0.1% versus ketotifen fumarate 0.05%." Acta Ophthalmol Scandinavica 78 (2000): 64-5

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