Norethindrone Side Effects
Some side effects of norethindrone may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to norethindrone: oral tablet
Get emergency medical help if you have any of these signs of an allergic reaction while taking norethindrone: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:
sudden numbness or weakness, especially on one side of the body;
sudden headache, confusion, pain behind the eyes, problems with vision, speech, or balance;
pain or swelling in one or both legs;
swelling in your hands or feet, rapid weight gain;
symptoms of depression (sleep problems, weakness, mood changes);
severe pelvic pain;
chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects of norethindrone may include:
mild nausea, vomiting, bloating, stomach cramps;
breast pain, swelling, or tenderness;
freckles or darkening of facial skin;
increased acne or hair growth;
changes in weight;
vaginal itching or discharge;
skin itching or rash;
changes in your menstrual periods, decreased sex drive; or
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.
For Healthcare Professionals
Applies to norethindrone: compounding powder, oral tablet
Genitourinary side effects have included breakthrough bleeding, spotting, change in menstrual flow, amenorrhea, changes in cervical erosion and secretion, and breast tenderness. Changes in the cervical squamocolumnar junction and cervical secretions have also been reported.
Endocrine side effects have included increases in PBI, BEI levels, and a decrease in T3 uptake.
Hematologic side effects have included an increase in prothrombin time and clotting factors VII, VIII, IX, and X.
Hepatic side effects have included hepatic adenomas and cholestatic jaundice.
Dermatologic side effects have included acne, melasma, chloasma, and pruritus.
General side effects have included weight gain/loss and hirsutism.
The psychiatric side effects have included mental depression.
Cardiovascular side effects have included edema
Gastrointestinal side effects have included nausea.
Nervous system side effects have included insomnia, headache and dizziness.
More norethindrone resources
- norethindrone Concise Consumer Information (Cerner Multum)
- norethindrone MedFacts Consumer Leaflet (Wolters Kluwer)
- Aygestin Monograph (AHFS DI)
- Aygestin Prescribing Information (FDA)
- Aygestin Oral, Implantation, Parenteral Advanced Consumer (Micromedex) - Includes Dosage Information
- Camila Prescribing Information (FDA)
- Errin Prescribing Information (FDA)
- Jolivette Prescribing Information (FDA)
- Nor-QD MedFacts Consumer Leaflet (Wolters Kluwer)
- Nor-QD Prescribing Information (FDA)
- Nora-BE Prescribing Information (FDA)
- Ortho Micronor Prescribing Information (FDA)
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