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Neumega Side Effects

Generic Name: oprelvekin

Note: This page contains side effects data for the generic drug oprelvekin. It is possible that some of the dosage forms included below may not apply to the brand name Neumega.

It is possible that some side effects of Neumega may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to oprelvekin: subcutaneous powder for solution

As well as its needed effects, oprelvekin (the active ingredient contained in Neumega) may cause unwanted side effects that require medical attention.

The side effects listed below include only those that might be caused by oprelvekin. To find out about other side effects that may be caused by the cancer medicines you are also receiving, see the information about those medicines.

If any of the following side effects occur while taking oprelvekin, check with your doctor or nurse as soon as possible:

More common
  • Fast heartbeat
  • fluid retention
  • irregular heartbeat
  • shortness of breath
  • sore mouth or tongue
  • swelling of feet or lower legs
  • white patches in mouth and/or on tongue
Less common
  • Bloody eye
  • blurred vision
  • severe redness and peeling of skin
Incidence not determined - —Observed during clinical practice with levofloxacin; estimates of frequency cannot be determined
  • bleeding
  • blistering
  • bloody urine
  • blurred vision
  • burning
  • change in ability to see colors, especially blue or yellow
  • cloudy urine
  • coldness
  • cough
  • decrease or increase in amount of urine
  • difficulty swallowing
  • discoloration of skin
  • dizziness
  • fainting or lightheadedness
  • fast heartbeat
  • feeling of pressure
  • hives
  • increased blood pressure
  • increased thirst
  • infection
  • inflammation
  • itching
  • loss of appetite
  • lower back/side pain
  • lumps
  • nausea
  • numbness
  • pain
  • puffiness or swelling of the eyelids or around the eyes face, lips or tongue
  • rash
  • redness
  • scarring
  • shortness of breath
  • skin rash
  • soreness
  • stinging
  • stomach pain;
  • swelling
  • tenderness
  • tightness in chest
  • tingling
  • troubled breathing
  • ulceration
  • unusual tiredness or weakness
  • vomiting
  • warmth at site
  • weight gain
  • wheezing

This medicine may also cause the following side effect that your doctor will watch for:

More common
  • Heart rhythm problems

Some oprelvekin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Red eyes
  • weakness
Less common
  • Numbness or tingling of hands or feet
  • skin discoloration
  • skin rash at place of injection

For Healthcare Professionals

Applies to oprelvekin: subcutaneous powder for injection


Cardiovascular side effects reported in clinical trials by the patients treated with oprelvekin (the active ingredient contained in Neumega) have included tachycardia (20%), vasodilation (19%), palpitations (14%), syncope (13%), atrial fibrillation/flutter (12%).[Ref]


Dermatologic side effects have included reports of rash in 25% of patients treated with oprelvekin (the active ingredient contained in Neumega) during clinical trials.[Ref]


Gastrointestinal side effects reported during clinical trials have included reports of nausea and vomiting, mucositis, diarrhea, and oral moniliasis in 14% of patients treated with oprelvekin (the active ingredient contained in Neumega) [Ref]

Nervous system

Nervous system side effects have included reports of dizziness and insomnia.[Ref]


Respiratory side effects have included reports of dyspnea (48%), rhinitis, increase in cough, pharyngitis, and pleural effusions (10%).[Ref]


Ocular side effects reported have included conjunctival infection and transient, mild visual blurring has occasionally been reported by patients treated with oprelvekin (the active ingredient contained in Neumega) [Ref]


General side effects most frequently reported include edema (59%), neutropenic fever, headache, and fever.[Ref]


Immunologic side effects reported have included the development of antibodies to oprelvekin (the active ingredient contained in Neumega) (1%). The clinical relevance of the presence of the antibodies is unknown. During the post-marketing setting, cases of allergic reactions with anaphylaxis have been reported.[Ref]


1. "Product Information. Neumega (oprelvekin)." Genetics Institute, Cambridge, MA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.