Neptazane Side Effects
Generic Name: methazolamide
Note: This page contains side effects data for the generic drug methazolamide. It is possible that some of the dosage forms included below may not apply to the brand name Neptazane.
It is possible that some side effects of Neptazane may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to methazolamide: oral tablets
Side effects include:
Paresthesia, hearing dysfunction or tinnitus, fatigue, malaise, anorexia, altered taste, nausea, vomiting, diarrhea, polyuria, drowsiness, confusion.
For Healthcare Professionals
Applies to methazolamide: compounding powder, oral tablet
Nervous system side effects have included paresthesias (most often a tingling in the extremities), hearing dysfunction, tinnitus, taste alteration, drowsiness, and confusion. Flaccid paralysis and convulsions have also been reported.[Ref]
Gastrointestinal side effects have included loss of appetite, nausea, vomiting, and diarrhea.[Ref]
Genitourinary side effects have included polyuria, hematuria, and glycosuria. Crystalluria and renal calculi have been reported rarely.[Ref]
Hypersensitivity reactions have included rare reports of toxic epidermal necrolysis, Stevens-Johnson syndrome, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias. Photosensitivity has been reported occasionally.[Ref]
Dermatologic side effects have included urticaria.[Ref]
Metabolic side effects have included metabolic acidosis and electrolyte disturbances.[Ref]
General side effects have included fatigue and malaise.[Ref]
Ocular side effects have included transient myopia. This can usually be resolved with a reduction in dose or discontinuation of therapy.[Ref]
Hepatic side effects have included hepatic insufficiency.[Ref]
1. "Product Information. Neptazane (methazolamide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
2. Fraunfelder FT, Meyer SM, Bagby GC Jr, Dreis MW "Hematologic reactions to carbonic anhydrase inhibitors." Am J Ophthalmol 100 (1985): 79-81
3. Gandham SB, Spaeth GL, Di Leonardo M, Costa VP "Methazolamide-induced skin eruptions." Arch Ophthalmol 111 (1993): 370-2
4. Moroi-Fetters SE, Metz EN, Chambers RB, Davidorf FH "Aplastic anemia with platelet autoantibodies in a patient after taking methazolamide." Am J Ophthalmol 110 (1990): 570-1
5. Shirato S, Kagaya F, Suzuki Y, Joukou S "Stevens-Johnson syndrome induced by methazolamide treatment." Arch Ophthalmol 115 (1997): 550-3
6. Cotter JB "Methazolamide-induced Stevens-Johnson syndrome: a warning!" Arch Ophthalmol 116 (1998): 117
7. Coudon WL, Block AJ "Acute respiratory failure precipitated by a carbonic anhydrase inhibitor." Chest 69 (1976): 112-3
8. Krivoy N, Ben-Arieh Y, Carter A, Alroy G "Methazolamide-induced hepatitis and pure RBC aplasia." Arch Intern Med 141 (1981): 1229-30
More about Neptazane (methazolamide)
Related treatment guides
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.