Navelbine Side Effects

Generic Name: vinorelbine

Note: This page contains side effects data for the generic drug vinorelbine. It is possible that some of the dosage forms included below may not apply to the brand name Navelbine.

It is possible that some side effects of Navelbine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to vinorelbine: intravenous solution

As well as its needed effects, vinorelbine (the active ingredient contained in Navelbine) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking vinorelbine, check with your doctor immediately:

More common
  • Cough or hoarseness, accompanied by fever or chills
  • fever or chills
  • lower back or side pain, accompanied by fever or chills
  • painful or difficult urination, accompanied by fever or chills
  • redness, increased warmth, pain, or discoloration of vein at place of injection
  • sore throat, accompanied by fever or chills
Less common
  • Chest pain
  • shortness of breath
  • sores in mouth and on lips
Rare
  • Black, tarry stools
  • bloating
  • blood in urine or stools
  • chills
  • darkened urine
  • fast heartbeat
  • fever
  • indigestion
  • loss of appetite
  • nausea
  • painful urination
  • pains in stomach
  • pinpoint red spots on skin
  • skin rash
  • unusual bleeding or bruising
  • vomiting
  • yellow eyes or skin

If any of the following side effects occur while taking vinorelbine, check with your doctor or nurse as soon as possible:

More common
  • Loss of strength and energy
  • unusual tiredness or weakness
Less common
  • Numbness or tingling in fingers and toes
Symptoms of overdose
  • Chest pain
  • cough or hoarseness, accompanied by fever or chills
  • fever or chills
  • heartburn
  • lower back or side pain, accompanied by fever or chills
  • mild abdominal pain and constipation
  • numbness or tingling in fingers and toes
  • painful or difficult urination, accompanied by fever or chills
  • sore throat, accompanied by fever or chills
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting

Some vinorelbine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Constipation
  • loss of appetite
  • nausea and vomiting
Less common
  • Diarrhea
  • jaw pain
  • joint or muscle pain

For Healthcare Professionals

Applies to vinorelbine: intravenous solution

Hematologic

Pulmonary embolus and deep venous thrombosis have primarily been reported in seriously ill and debilitated patients with known predisposing risk factors for these events.

Hematologic side effects have included granulocytopenia, which has been the major dose-limiting toxicity with the use of vinorelbine. Granulocytopenia has been reported at a frequency of 90% of patients with less than 2,000 cells/mm3 and 36% of patients with less than 500 cells/mm3. Leukopenia has been reported at a frequency of 92% of patients with less than 4,000 cells/mm3 and 5% of patients with less than 1,000 cells/mm3. Thrombocytopenia has been reported at a frequency of 5% of patients with less than 100,000 cells/mm3 and 1% of patients with less than 50,000 cells/mm3. And finally, anemia has been reported at a frequency of 83% of patients with less than 11 g/dL and 9% of patients with less than 8 g/dL. Pulmonary embolus and deep venous thrombosis have also been reported.

Hepatic

Hepatic side effects including an increase in SGOT (67%) and an increase in total bilirubin (13%) have been reported.

Gastrointestinal

Gastrointestinal side effects including nausea (44%), constipation (35%), vomiting (20%), diarrhea (17%), dysphagia, and mucositis have been reported. A case of typhlitis (neutropenic enterocolitis) has also been reported.

General

General side effects including asthenia (36%), fatigue (27%), back pain, abdominal pain, and pain in tumor containing tissues have been reported.

Fatigue was usually mild or moderate and tended to increase with increased cumulative dosing.

Local

Local side effects including injection site reactions (28%) and injection site pain (16%) have been reported.

Nervous system

Nervous system side effects including peripheral neuropathy (paresthesia and hypesthesia) (25%) and headache have been reported.

Dermatologic

Some of these dermatologic reactions have been delayed in their occurrence.

Dermatologic side effects including alopecia (12%), rash (<5%), pruritus, blister formation, skin sloughing, and urticaria have been reported.

Cardiovascular

Most of the chest pain has been reported to have occurred in patients who had either a history of cardiovascular disease or tumor within the chest.

Cardiovascular side effects including phlebitis (7%), chest pain (5%), myocardial infarction, angioedema, hypertension, hypotension, vasodilation, tachycardia, and flushing have been reported.

Respiratory

Respiratory side effects including dyspnea (7%), shortness of breath (3%), severe shortness of breath (2%), pulmonary edema, and pneumonia have been reported.

Musculoskeletal

Musculoskeletal side effects including jaw pain, myalgia, and arthralgia have been reported in less than 5% of patients.

Genitourinary

Genitourinary side effects including hemorrhagic cystitis (<1%) have been reported.

Metabolic

Metabolic side effects including the syndrome of inappropriate antidiuretic hormone (<1%) have been reported.

Hypersensitivity

Hypersensitivity side effects including anaphylaxis have been reported.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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