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Methyclothiazide Side Effects

For the Consumer

Applies to methyclothiazide: oral tablet

In addition to its needed effects, some unwanted effects may be caused by methyclothiazide. In the event that any of these side effects do occur, they may require medical attention.

Severity: Major

You should check with your doctor immediately if any of these side effects occur when taking methyclothiazide:

Incidence not known
  • Abdominal or stomach pain
  • back, leg, or stomach pains
  • black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of skin
  • bloating
  • blood in urine or stools
  • bloody urine
  • blue lips and fingernails
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • chills
  • clay-colored stools
  • cloudy urine
  • cold sweats
  • confusion
  • constipation
  • cough or hoarseness
  • coughing that sometimes produces a pink frothy sputum
  • coughing up blood
  • cracks in the skin
  • darkened urine
  • decrease in urine output or decrease in urine-concentrating ability
  • decreased frequency or amount of urine
  • diarrhea
  • difficult, fast, or noisy breathing, sometimes with wheezing
  • difficulty swallowing
  • dizziness, faintness, or lightheadedness when getting up from lying or sitting position
  • dry mouth
  • fast or irregular heartbeat
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • general body swelling
  • general feeling of discomfort or illness
  • general feeling of tiredness or weakness
  • greatly decreased frequency of urination or amount of urine
  • headache
  • hives
  • increased blood pressure
  • increased hunger
  • increased sweating
  • increased thirst
  • increased urination
  • indigestion
  • itching
  • joint pain, stiffness, or swelling
  • loss of appetite
  • loss of heat from the body
  • lower back or side pain
  • muscle cramps or pain
  • nausea or vomiting
  • nosebleeds
  • numbness, tingling, pain, or weakness in hands or feet
  • pain in joints or muscles
  • painful or difficult urination
  • pains in stomach, side, or abdomen, possibly radiating to the back
  • pale skin
  • pinpoint red spots on skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • red, swollen skin
  • redness, soreness, or itching skin
  • scaly skin
  • seizures
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on lips or in mouth
  • sores, welting or blisters
  • sugar in the urine
  • swelling of face, fingers, legs, ankles, feet, or lower legs
  • swollen or painful glands
  • tenderness of salivary glands
  • thickening of bronchial secretions
  • tightness in chest
  • trembling
  • troubled breathing
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight loss
  • vomiting of blood
  • weakness and heaviness of legs
  • weight gain
  • wheezing
  • yellow eyes or skin

Severity: Minor

Some of the side effects that can occur with methyclothiazide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known
  • Cramping
  • decreased interest in sexual intercourse
  • difficulty having a bowel movement (stool)
  • feeling of constant movement of self or surroundings
  • hair loss, thinning of hair
  • inability to have or keep an erection
  • increased sensitivity of skin to sunlight
  • loss in sexual ability, desire, drive, or performance
  • muscle spasm
  • pinpoint red or purple spots on skin
  • redness or other discoloration of skin
  • restlessness
  • sensation of spinning
  • severe sunburn
  • weakness

For Healthcare Professionals

Applies to methyclothiazide: compounding powder, oral tablet

Gastrointestinal

Frequency not reported: Pancreatitis, sialadenitis, vomiting, diarrhea, nausea, gastric irritation, constipation[Ref]

Dermatologic

Frequency not reported: Cutaneous vasculitis, purpura, urticaria, rash, photosensitivity[Ref]

Hematologic

Frequency not reported: Aplastic anemia, hemolytic anemia, agranulocytosis, leukopenia, thrombocytopenia[Ref]

Metabolic

Frequency not reported: Anorexia, hyperglycemia, hyperuricemia, electrolyte imbalance, hypercalcemia[Ref]

Nervous system

Frequency not reported: Headache, vertigo, dizziness, paresthesias[Ref]

Respiratory

Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema[Ref]

Cardiovascular

Frequency not reported: Orthostatic hypotension, vasculitis[Ref]

Immunologic

Frequency not reported: Anaphylactic reaction, Stevens-Johnson syndrome[Ref]

Musculoskeletal

Frequency not reported: Cramping, muscle spasm[Ref]

Ocular

Frequency not reported: Transient blurred vision, xanthopsia[Ref]

Other

Frequency not reported: Weakness, fever[Ref]

Genitourinary

Frequency not reported: Glycosuria[Ref]

Hepatic

Frequency not reported: Intrahepatic cholestatic jaundice[Ref]

Psychiatric

Frequency not reported: Restlessness[Ref]

References

1. "Product Information. Enduron (methyclothiazide)." Abbott Pharmaceutical, Abbott Park, IL.

Not all side effects for methyclothiazide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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