Mandol Side Effects
Generic Name: cefamandole
Note: This page contains information about the side effects of cefamandole. Some of the dosage forms included on this document may not apply to the brand name Mandol.
Not all side effects for Mandol may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
Applies to cefamandole: injectable powder for injection
Gastrointestinal side effects, such as nausea and vomiting, are rare, and are more likely to occur if the patient consumes alcohol. This is due to inactivation of aldehyde dehydrogenase by cefamandole (the active ingredient contained in Mandol) which causes an accumulation of acetaldehyde and a disulfiram-like reaction in the presence of alcohol. Pseudomembranous colitis has been associated with cefamandole therapy.
Hepatic abnormalities, such as increases in serum transaminases, are usually mild and transient, and return to normal within two weeks after therapy is stopped. In most cases these changes do not necessitate drug discontinuation.
Toxic epidermal necrolysis (TEN) is reported with cefamandole (the active ingredient contained in Mandol) therapy. In one case, TEN occurred approximately ten days following a ten-day course of cefamandole for pneumonia. Intravenous steroids were initiated; however, the patient again developed pneumonia and succumbed to septic shock.
Erythema multiforme is also associated with cefamandole therapy. One affected patient had known allergies to penicillin and sulfonamides and a history of eczematous dermatitis. She was given cefamandole for fever of unknown origin. Within three days of starting therapy, she developed red, tender plaques, some of which progressed to large bullae. Treatment with intravenous steroids improved her skin condition.
A case of occupational contact dermatitis due to cephalosporin allergy has been reported in a nurse who prepared cephalosporin solutions for administration to patients. The dermatitis resolved after the nurse stopped preparing the solutions.
Hypersensitivity reactions, such as rash, may occur. Cross-reactivity may occur in penicillin allergic patients. Toxic epidermal necrolysis and erythema multiforme have been reported in cefamandole treated patients.
Hematologic side effects can be clinically significant. Cefamandole-induced hypoprothrombinemia may be associated with clinically significant bleeding. Vitamin K may correct the coagulopathy, although in most cases, substitution with another antibiotic will be necessary. In rare cases, transfusion of fresh frozen plasma or whole blood may be needed.
New or worsened renal insufficiency has only rarely been associated with cefamandole (the active ingredient contained in Mandol)
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