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Lutropin alfa Side Effects

For the Consumer

Applies to lutropin alfa: subcutaneous powder for solution

In addition to its needed effects, some unwanted effects may be caused by lutropin alfa. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking lutropin alfa, check with your doctor or nurse immediately:

More common:
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • bloating
  • diarrhea
  • stomach or pelvic discomfort, aching, or heaviness
Incidence not known (Observed after pregnancy)
  • Congenital abnormalities
  • ectopic pregnancy
  • postpartum fever
  • premature labor
  • spontaneous abortion
Incidence not known (Observed during menotropin therapy)
  • Adnexal torsion as a complication of ovarian enlargement
  • blood in the peritoneal cavity
  • changes in skin color
  • cold hands and feet
  • ovarian enlargement (mild to moderate)
  • pain, redness, or swelling in the arm or leg
  • troubled breathing

If any of the following symptoms of overdose occur while taking lutropin alfa, get emergency help immediately:

Symptoms of overdose:
  • Abdominal or stomach pain
  • bloating
  • multiple gestation
  • rapid weight gain
  • severe nausea
  • vomiting

Severity: Minor

Some of the side effects that can occur with lutropin alfa may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Bloated or full feeling
  • breast pain
  • excess air or gas in the stomach or intestines
  • headache
  • pain
  • passing gas
  • unusual tiredness or weakness
Less common:
  • Body aches or pain
  • chills
  • cough
  • cramps
  • difficulty having a bowel movement (stool)
  • difficulty with breathing
  • ear congestion
  • fever
  • heavy bleeding
  • loss of voice
  • nasal congestion
  • ovarian disorder
  • pain
  • runny nose
  • sneezing
  • sore throat

For Healthcare Professionals

Applies to lutropin alfa: subcutaneous powder for injection


Cardiovascular side effects have included arterial thromboembolism.[Ref]


Gastrointestinal side effects have included nausea, flatulence, diarrhea and constipation.[Ref]


Genitourinary side effects have included ovarian hyperstimulation (sometimes leading to ovarian enlargement or ovarian hyperstimulation syndrome), ovarian cysts, ovarian disorders, dysmenorrhea, and breast pain.[Ref]


General side effects have included pain and fatigue.[Ref]


Musculoskeletal side effects have included abdominal pain.[Ref]


Local side effects have included injection site reactions.[Ref]

Nervous system

Nervous system side effects have included headache.[Ref]


Respiratory side effects have included upper respiratory tract infections.[Ref]


1. "Product Information. Luveris (lutropin alfa)." Serono Laboratories Inc, Rockland, MA.

Not all side effects for lutropin alfa may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.