Medication Guide App

Kcentra Side Effects

Generic Name: prothrombin complex

Note: This page contains side effects data for the generic drug prothrombin complex. It is possible that some of the dosage forms included below may not apply to the brand name Kcentra.

It is possible that some side effects of Kcentra may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Applies to prothrombin complex: intravenous powder for injection

General

The most common adverse reactions were headache, nausea/vomiting, arthralgia, and hypotension.

The most serious adverse reactions were thromboembolic events including stroke, pulmonary embolism, and deep vein thrombosis.

Cardiovascular

Common (1% to 10%): Hypotension (4.9%), tachycardia (2.9%), increased blood pressure/hypertension (2.9%)
Uncommon (0.1% to 1%): Venous thrombosis, calf (1.0%), deep vein thrombosis (1.0%), fistula clot (1.0%)
Postmarketing reports: Arterial thromboembolic events (including acute myocardial infarction and arterial thrombosis), venous thromboembolic events (including pulmonary embolism and venous thrombosis), and disseminated intravascular coagulation

Gastrointestinal

Common (1% to 10%): Nausea/vomiting (3.9%), constipation (1.9%)

Hypersensitivity

Postmarketing reports: Flushing, urticaria, tachycardia, anxiety, angioedema, wheezing, nausea, vomiting, hypotension, tachypnea, dyspnea, pulmonary edema, and bronchospasm

Metabolic

Common (1% to 10%): International normalized ratio increased (2.9%), hypokalemia (1.9%)
Uncommon (0.1% to 1%): Fluid overload (1.0%)

Musculoskeletal

Common (1% to 10%): Arthralgia (3.9%)
Uncommon (0.1% to 1%): Chest pain (1.0%)

Nervous system

Common (1% to 10%): Headache (7.8%), hemorrhage intracranial (2.9%), ischemic cerebrovascular accident (1.9%)

Other

Common (1% to 10%): Skin laceration/contusion/subcutaneous hematoma (2.9%)
Uncommon (0.1% to 1%): Sudden death, unknown cause (1.0%)

Psychiatric

Common (1% to 10%): Mental status changes (1.9%)
Uncommon (0.1% to 1%): Insomnia (1.0%)

Respiratory

Common (1% to 10%): Respiratory distress/dyspnea/hypoxia (1.9%)
Uncommon (0.1% to 1%): Abnormal breath sounds/rales (1.0%)

More about Kcentra (prothrombin complex)

Consumer resources

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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