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Immune globulin intramuscular Side Effects

Not all side effects for immune globulin intramuscular may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to immune globulin intramuscular: injection (im)

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Pain, swelling, tenderness, or redness at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur while taking immune globulin intramuscular:

Severe allergic reactions (rash; itching; hives; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, hands, face, lips, eyes, throat, or tongue).

For Healthcare Professionals

Applies to immune globulin intramuscular: intramuscular solution


Local injection site pain and tenderness have occurred.[Ref]


Hypersensitivity reactions have been rare, however, anaphylaxis has been reported. The mechanism has not been clearly established. Activation of the complement system by immune globulin aggregates present in the preparations has been suggested.[Ref]


All U.S. immune globulin products undergo viral inactivation and/or removal. No method has been totally effective in removing all risk and the potential exists for the presence of unknown infectious agents.[Ref]


1. Gardulf A, Hammarstrom L, Smith CI "Home treatment of hypogammaglobulinaemia with subcutaneous gammaglobulin by rapid infusion." Lancet 338 (1991): 162-6

2. "Product Information. BayGam (immune globulin intramuscular)" Bayer, West Haven, CT.

3. Kamme C, Coster C, Hagelquist E, Kalen N, Lindholm H, Grubb R "Side effects of treatment of hypogammaglobulinaemia with gammaglobulin." Acta Med Scand 179 (1966): 679-90

4. Kleinman PK, Weksler ME "Repeated reactions following intramuscular injection of gamma globulin." J Pediatr 83 (1973): 827-9

5. Pollack S, Cunningham-Rundles C, Good RA, Day NK "C1 esterase inhibitor deficiency in X-linked hypogammaglobulinaemia: an anomaly fostering anaphylactoid reactions following intramuscula gammaglobulin administration." Postgrad Med J 62 (1986): 939-42

6. Soothill JF "Hypogammaglobulinaemia in the United Kingdom. XI. Reactions to immunoglobulin." Med Res Counc Spec Rep Ser (Lond) 310 (1971): 106-14

7. Shemin ER "Anaphylactic reaction to gamma-globulin." JAMA 203 (1968): 59

8. Frankel SJ, Polmar SH, Grumet FC, Wedner HJ "Anti-IgA antibody associated reactions to intravenous gammaglobulin in a patient who tolerated intramuscular gammaglobulin." Ann Allergy 56 (1986): 436-9

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