Imfinzi Side Effects

Generic name: durvalumab

Medically reviewed by Drugs.com. Last updated on Apr 7, 2023.

Note: This document contains side effect information about durvalumab. Some dosage forms listed on this page may not apply to the brand name Imfinzi.

Applies to durvalumab: intravenous solution.

Serious side effects of Imfinzi

Along with its needed effects, durvalumab (the active ingredient contained in Imfinzi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking durvalumab:

More common

Bladder pain
bloating or swelling of the face, arms, hands, lower legs, or feet
bloody or cloudy urine
body aches or pain
chest pain or tightness
chills
cough
depressed mood
difficult, burning, or painful urination
difficulty having a bowel movement
dry skin and hair
ear congestion
feeling cold
fever
frequent urge to urinate
general feeling of discomfort or illness
headache
hoarseness, husky, or loss of voice
lower back or side pain
muscle cramps and stiffness
nervousness
runny or stuffy nose
sensitivity to heat
slowed heartbeat
sneezing
sore throat
stomach cramps
sweating
tenderness
thickening of bronchial secretions
tingling of the hands or feet
trouble breathing
trouble sleeping
unusual tiredness or weakness
unusual weight gain or loss
watery or bloody diarrhea

Less common

Back, leg, or stomach pains
black, tarry stools
bleeding gums
bloody nose
blurred vision or other changes in vision
dark urine
eye redness, irritation, or pain
general body swelling
heavier menstrual periods
light-colored stools
loss of appetite
nausea
nosebleeds
pale skin
pinpoint red spots on the skin
sensitivity of the eye to light
skin rash
stiff neck or back
tearing
unusual bleeding or bruising
upper right abdominal or stomach pain
vomiting
yellow eyes and skin

Rare

Blistering, peeling, or loosening of the skin
dizziness
drowsiness
fainting
joint or muscle pain
red skin lesions, often with a purple center
sores, ulcers, or white spots in the mouth or on the lips
swollen glands

Other side effects of Imfinzi

Some side effects of durvalumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Constipation
lack or loss of strength
loss or thinning of the hair

For Healthcare Professionals

Applies to durvalumab: intravenous solution.

Endocrine

Common (1% to 10%): Immune-mediated endocrinopathies (e.g., hypothyroidism, hyperthyroidism, adrenal insufficiency, type 1 diabetes mellitus, hypophysitis/hypopituitarism)^[Ref]

Dermatologic

Very common (10% or more): Rash (dermatitis, dermatitis acneiform, dermatitis psoriasiform, psoriasis, rash maculopapular, rash pruritic, rash papular, rash pustular, skin toxicity, eczema, erythema, erythema multiforme, rash erythematous, acne, lichen planus) (11%)^[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Immune-related myocarditis^[Ref]

Hematologic

Very common (10% or more): Lymphopenia (11%)

Common (1% to 10%): Anemia^[Ref]

Genitourinary

Very common (10% or more): Urinary tract infection (e.g., cystitis, candiduria, urosepsis) (15%)^[Ref]

Gastrointestinal

Very common (10% or more): Constipation (21%), nausea (16%), abdominal pain (upper, lower, flank) (14%), diarrhea/colitis (13%)

Common (1% to 10%): Dehydration

Frequency not reported: Immune-mediated colitis^[Ref]

Hepatic

Common (1% to 10%): Liver injury, immune-mediated hepatitis

Uncommon (0.1% to 1%): Increased ASO, increased ALT, hyperbilirubinemia

Frequency not reported: Immune-mediated hepatitis^[Ref]

Metabolic

Very common (10% or more): Decreased appetite/hypophagia (19%), hyponatremia (12%)

Common (1% to 10%): Deterioration of general physical health, increased alkaline phosphatase, hypermagnesemia, hypercalcemia, hyperglycemia, neutropenia, hyperkalemia, hypoalbuminemia^[Ref]

Local

Common (1% to 10%): Infusion-related reactions^[Ref]

Immunologic

Common (1% to 10%): Infections (e.g., sepsis, necrotizing fasciitis, osteomyelitis)^[Ref]

Ocular

Uncommon (0.1% to 1%): Uveitis and keratitis^[Ref]

Musculoskeletal

Very common (10% or more): Musculoskeletal pain (e.g., back pain, musculoskeletal chest pain, musculoskeletal pain and discomfort, myalgia, neck pain) (24%)^[Ref]

Nervous system

Common (1% to 10%): Pyrexia/tumor associated fever

Uncommon (0.1% to 1%): Immune-related aseptic meningitis^[Ref]

Other

Very common (10% or more): Fatigue (e.g., asthenia, lethargy, malaise) (39%), peripheral edema (e.g., edema, localized edema, edema peripheral, lymphedema, peripheral swelling, scrotal edema, scrotal swelling) (15%), pyrexia/tumor associated fever (14%)

Common (1% to 10%): Embryofetal toxicity^[Ref]