Hydroxyzine Side Effects

Not all side effects for hydroxyzine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to hydroxyzine: oral capsules, oral suspension or solution, parenteral injection

Side effects include:

Drowsiness, dry mouth.

For Healthcare Professionals

Applies to hydroxyzine: compounding powder, intramuscular solution, oral capsule, oral suspension, oral syrup, oral tablet

Nervous system

Nervous system side effects have included moderate to slight drowsiness. This effect is usually transitory and may disappear with continued therapy or upon discontinuation of the agent. Headache, fatigue, depression, insomnia, sedation, and nervousness have also been reported with hydroxyzine. With higher than recommended doses of hydroxyzine, involuntary motor activity such as tremor and convulsions have been reported in rare instances.

Gastrointestinal

Gastrointestinal side effects have included dry mouth (most common side effect), nausea, diarrhea, abdominal pain, and increases in weight and appetite.

Respiratory

Respiratory side effects have included the thickening of bronchial secretions. Rare occurrences of pharyngitis, bronchospasm, and epistaxis have also been reported.

Cardiovascular

Cardiovascular side effects have included palpitations, hypotension, and edema.

Dermatologic

Dermatologic side effects have included angioedema, photosensitivity, and rash.

Genitourinary

Genitourinary side effects have included rare cases of urinary retention and prolonged penile erections.

Ocular

Ocular side effects have included blurred vision.

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