Hydroxyzine Side Effects

Some side effects of hydroxyzine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to hydroxyzine: oral capsule, oral syrup, oral tablet

Get emergency medical help if you have any of these signs of an allergic reaction while taking hydroxyzine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using hydroxyzine and call your doctor at once if you have a serious side effect such as:

• restless muscle movements in your eyes, tongue, jaw, or neck;

• tremor (uncontrolled shaking);

• confusion; or

• seizure (convulsions).

Less serious side effects of hydroxyzine may include:

• dizziness, drowsiness;

• blurred vision, dry mouth; or

• headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to hydroxyzine: compounding powder, intramuscular solution, oral capsule, oral suspension, oral syrup, oral tablet

Nervous system

Nervous system side effects have included moderate to slight drowsiness. This effect is usually transitory and may disappear with continued therapy or upon discontinuation of the agent. Headache, fatigue, depression, insomnia, sedation, and nervousness have also been reported with hydroxyzine. With higher than recommended doses of hydroxyzine, involuntary motor activity such as tremor and convulsions have been reported in rare instances.

Gastrointestinal

Gastrointestinal side effects have included dry mouth (most common side effect), nausea, diarrhea, abdominal pain, and increases in weight and appetite.

Respiratory

Respiratory side effects have included the thickening of bronchial secretions. Rare occurrences of pharyngitis, bronchospasm, and epistaxis have also been reported.

Cardiovascular

Cardiovascular side effects have included palpitations, hypotension, and edema.

Dermatologic

Dermatologic side effects have included angioedema, photosensitivity, and rash.

Genitourinary

Genitourinary side effects have included rare cases of urinary retention and prolonged penile erections.

Ocular

Ocular side effects have included blurred vision.

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