Hydroxyzine Dosage

Usual Adult Dose for Anxiety

50 to 100 mg orally or by IM injection 4 times a day.

Usual Adult Dose for Pruritus

For pruritus due to an allergic condition (chronic urticaria, atopic and contact dermatoses, or histamine mediated pruritus):

25 mg orally or by IM injection 3 to 4 times a day.

Usual Adult Dose for Sedation

Before and after general anesthesia:

50 to 100 mg orally or by IM injection.

Usual Adult Dose for Pain

25 to 100 mg by IM injection pre- or postoperatively or postpartum.

Usual Adult Dose for Nausea/Vomiting

25 to 100 mg by IM injection pre- or postoperatively or postpartum.

Usual Pediatric Dose for Sedation

As a sedative when used as a premedication and following general anesthesia:
oral: 0.6 mg/kg/dose
intramuscular: 0.5 to 1 mg/kg/dose

Usual Pediatric Dose for Anxiety

For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested and in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses, and in histamine mediated pruritus:

less than 6 years of age:
50 mg orally per day in divided doses
6 years and older:
50 to 100 mg orally per day in divided doses

Alternative dosing:
Oral: 2 mg/kg/day divided every 6 to 8 hours
Intramuscular: 0.5 to 1 mg/kg/dose every 4 to 6 hours as needed

Usual Pediatric Dose for Pruritus

For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested and in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses, and in histamine mediated pruritus:

less than 6 years of age:
50 mg orally per day in divided doses
6 years and older:
50 to 100 mg orally per day in divided doses

Alternative dosing:
Oral: 2 mg/kg/day divided every 6 to 8 hours
Intramuscular: 0.5 to 1 mg/kg/dose every 4 to 6 hours as needed

Usual Pediatric Dose for Nausea/Vomiting

intramuscular: 1.1 mg/kg/dose

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Limited clinical data indicate that the elimination of hydroxyzine is decreased in patients with hepatic dysfunction secondary to primary biliary cirrhosis. Change dosing interval to every 24 hours in patients with primary biliary cirrhosis.

Dialysis

Data not available

Other Comments

Parenteral hydroxyzine is for deep IM administration only.

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